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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Nature Genetics, Volume 45, No. 6, Year 2013
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Description
We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination. © 2013 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Miotto, Olivo
Unknown Affiliation
Almagro-Garcia, Jacob
Unknown Affiliation
Manske, Heinrich Magnus
Unknown Affiliation
MacInnis, Bronwyn L.
Unknown Affiliation
Campino, Susana G.
Unknown Affiliation
Rockett, Kirk A.
Unknown Affiliation
Amaratunga, Chanaki
Unknown Affiliation
Lim, Pharath
Unknown Affiliation
Suon, Seila
Unknown Affiliation
Sreng, Sokunthea
Unknown Affiliation
Anderson, Jennifer M.
Unknown Affiliation
Socheat, Duong
Unknown Affiliation
Nguon, Chea
Unknown Affiliation
Chuor, Char Meng
Unknown Affiliation
Saunders, David L.
Unknown Affiliation
Se, Youry
Unknown Affiliation
Lon, Chanthap
Unknown Affiliation
Fukuda, Mark M.
Unknown Affiliation
Amenga-Etego, Lucas Naam Kayagre
Unknown Affiliation
Hodgson, Abraham V.O.
Unknown Affiliation
Asoala, Victor
Unknown Affiliation
Imwong, Mallika
Unknown Affiliation
Takala-Harrison, Shannon L.
Unknown Affiliation
Nosten, François Henry
Unknown Affiliation
Su, Xinzhuan
Unknown Affiliation
Ringwald, Pascal
Unknown Affiliation
Ariey, Frédéric
Unknown Affiliation
Dolecek, Christiane
Unknown Affiliation
Hien, Tran Tinh
Unknown Affiliation
Boni, Maciej F.
Unknown Affiliation
Thai, Cao Quang
Unknown Affiliation
Amambua-Ngwa, Alfred
Unknown Affiliation
Conway, David J.
Unknown Affiliation
Djimde, Abdoulaye A.
Unknown Affiliation
Doumbo, Ogobara K.
Unknown Affiliation
Zongo, Issaka D.
Unknown Affiliation
Ouedraogo, Jean Bosco
Unknown Affiliation
Alcock, Dan
Unknown Affiliation
Drury, Eleanor
Unknown Affiliation
Auburn, Sarah A.
Unknown Affiliation
Koch, Oliver
Unknown Affiliation
Sanders, Mandy J.
Unknown Affiliation
Hubbart, Christina S.
Unknown Affiliation
Maslen, Gareth Ll
Unknown Affiliation
Ruano-Rubio, Valentín
Unknown Affiliation
Jyothi, Dushyanth
Unknown Affiliation
Miles, Alistair J.
Unknown Affiliation
O'Brien, John D.
Unknown Affiliation
Gamble, Chris
Unknown Affiliation
Oyola, Samuel O.
Unknown Affiliation
Rayner, Julian C.
Unknown Affiliation
Newbold, Chris I.
Unknown Affiliation
Berriman, Matthew
Unknown Affiliation
Spencer, Chris C.A.
Unknown Affiliation
McVean, Gil
Unknown Affiliation
Day, Nichloas P.J.
Unknown Affiliation
White, Nicholas J.
Unknown Affiliation
Bethell, Delia B.
Unknown Affiliation
Dondorp, A. M.
Unknown Affiliation
Plowe, Christopher Vv
Unknown Affiliation
Fairhurst, Rick M.
Unknown Affiliation
Kwiatkowski, Dominic P.
Unknown Affiliation
Statistics
Citations: 436
Authors: 62
Affiliations: 22
Identifiers
Doi:
10.1038/ng.2624
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study