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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Obesity: An important prognostic factor in acute pancreatitis
British Journal of Surgery, Volume 80, No. 4, Year 1993
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Description
Ninety‐nine patients with acute pancreatitis in whom body mass index (BMI = weight (kg)/height2 (m2)) was measured were studied prospectively to determine the importance of obesity as a prognostic factor in this disease. Of 19 obese patients (BMI ⩾ 30 kg/m2), 12 developed severe pancreatitis; seven had abscesses, of whom five died, and two further patients died. In 80 non‐obese patients, the incidence of severe pancreatitis (n =5), abscess formation (n = 4) and death (n = 4) was significantly less (P = 0.0007). The mean(s.d.) BMI of 17 patients with severe acute pancreatitis was significantly higher than that in 82 patients with mild acute disease (31.2(5.6) versus 23.3(5.6) kg/m2, P <0.001). As a single prognostic factor, obesity had a sensitivity of 63 per cent and a specificity of 95 per cent for predicting disease severity. When five obese women with gallstone pancreatitis were excluded, the sensitivity of obesity increased to 86 per cent. Severe pancreatitis occurred in all eight obese patients with disease of an alcoholic aetiology. These data suggest that increased fat deposits in the peripancreatic and retroperitoneal spaces in obese patients may increase the risk of peripancreatic fat necrosis, abscess and death. Consideration should be given to including obesity as a prognostic factor in acute pancreatitis. Copyright © 1993 British Journal of Surgery Society Ltd.
Authors & Co-Authors
Funnell, I. C.
South Africa, Cape Town
University of Cape Town
Bornman, Philippus C.
South Africa, Cape Town
University of Cape Town
Weakley, S. P.
South Africa, Cape Town
University of Cape Town
Terblanche, John T.
South Africa, Cape Town
University of Cape Town
Marks, Israel N.Solly
South Africa, Observatory
Groote Schuur Hospital
Statistics
Citations: 193
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1002/bjs.1800800426
ISSN:
00071323
e-ISSN:
13652168
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study
Participants Gender
Female