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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Hormonal regulation of the mouse adrenal melanocortinergic system
Journal of Endocrinological Investigation, Volume 32, No. 1, Year 2009
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Description
Adrenocortical cells of several species have been reported to express significant levels of Agouti-related protein (Agrp) as well as melanocortin 4-receptor (MC4-R). In this study, we used the mouse tumoral adrenal cell line ATC7-L that secretes corticosterone in basal conditions with a 2-fold increase in response to ACTH treatment. We reported that these cells expressed functional MC4-R. They also expressed Agrp mRNA and secreted immunoreactive Agrp, in the culture medium. Long-term treatment of ATC7-L with (Nle4, D-Phe7)-αMSH (NDP-αMSH) or forskolin as well as Agrp strongly reduced MC4-R level by more than 30%. On the contrary, leptin treatment did not modify this level although it significantly reduced MC2-R level. These results could be correlated to some data obtained in vivo on adrenal glands removed from diet-induced obese mice exhibiting a hyperleptinemia, where the level of both MC2-R and MC4-R appeared to be reduced as Agrp mRNA expression level was increased compared to Control mice. All these data would suggest the existence of a link between the metabolic status and the activation of the adrenal melanocortinergic system. © 2009, Editrice Kurtis.
Authors & Co-Authors
Soltani, Yacine
France, Villeurbanne
Université Claude Bernard Lyon 1
France, Lyon
Université de Lyon
France, Paris
Inserm
Algeria, Algiers
Université Des Sciences et de la Technologie Houari Boumediene
Doghman-Bouguerra, Mabrouka
France, Valbonne
Institut de Pharmacologie Moléculaire et Cellulaire
Gout, J.
France, Villeurbanne
Université Claude Bernard Lyon 1
France, Lyon
Université de Lyon
France, Paris
Inserm
Rebuffet, V.
France, Villeurbanne
Université Claude Bernard Lyon 1
France, Lyon
Université de Lyon
France, Paris
Inserm
Vigier, M.
France, Villeurbanne
Université Claude Bernard Lyon 1
France, Lyon
Université de Lyon
France, Paris
Inserm
Bekkouche, F. Hadj
Algeria, Algiers
Université Des Sciences et de la Technologie Houari Boumediene
Naville, D.
France, Villeurbanne
Université Claude Bernard Lyon 1
France, Lyon
Université de Lyon
France, Paris
Inserm
Begeot, Martine
France, Villeurbanne
Université Claude Bernard Lyon 1
France, Lyon
Université de Lyon
France, Paris
Inserm
Statistics
Citations: 8
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1007/BF03345678
ISSN:
03914097
Research Areas
Noncommunicable Diseases