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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles
Cancer Letters, Volume 347, No. 1, Year 2014
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Description
High atomic number molecules, such as gold and platinum, are known to enhance the biological effect of X-irradiation. This study was aimed to determine the radiosensitizing potential of PEGylated nanogel containing gold nanoparticles (GNG) and the cellular mechanism involved. GNG pretreatment increased the levels of reproductive cell death and apoptosis induced by X-irradiation. GNG accumulated in cytoplasm and increased the expression of endoplasmic reticulum (ER) stress-related protein. GNG suppressed the repair capacity of DNA after X-irradiation by down-regulating DNA repair-related proteins. Our results suggest that GNG radiosensitized cells by enhancing apoptosis and impairing DNA repair capacity via ER stress induction. © 2014 Elsevier Ireland Ltd.
Authors & Co-Authors
Ikenaka, Yoshinori
Japan, Sapporo
Hokkaido University
Kon, Yoshihiro
Japan, Sapporo
Hokkaido University
Statistics
Citations: 64
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/j.canlet.2014.02.005
ISSN:
03043835
Research Areas
Cancer
Genetics And Genomics
Sexual And Reproductive Health