Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
RNA detection and subtype C assessment of HIV-1 in infants with diarrhea in Ethiopia
Open AIDS Journal, Volume 3, Year 2009
Notification
URL copied to clipboard!
Description
In the absence of chemoprophylaxis, HIV-1 transmission occurs in 13-42% of infants born to HIV-1 positive mothers. All exposed infants acquire maternal HIV-1 antibodies that persist for up to 15 months, thereby hampering diagnosis. In resource limited settings, clinical symptoms are the indices of established infection against validated laboratorybased markers. Here we enrolled 1200 children hospitalized for diarrheal and other illnesses. 20-25% of those tested, aged 15 months or younger, were found to be HIV-1-seropositive. Where sufficient plasma was available, HIV-1 RNA detection was performed using a subtype-insensitive assay, with 71.1% of seropositive infants presenting with diarrhea showing positive. From sub-typing analysis, we identified that viruses of the C' sub-cluster were predominated amongst infants. Although this study may overestimate the HIV-1 frequency through testing symptomatic infants, diarrhea can be seen as a useful marker indicating HIV-1 infection in infants less than 15 months old. © Ayele et al.
Authors & Co-Authors
Ayele, Workenesh
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Assefa, Tsehai
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Lulseged, Sileshi
Ethiopia, Addis Ababa
Addis Ababa University
Tegbaru, Belete
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Berhanu, Hiwot
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Tamene, Wegene
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Ahmedin, Zenit
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Tensai, Birzaf W.
Ethiopia, Addis Ababa
Yekatit 12 Hospital
Tafesse, Mengistu
Ethiopia, Addis Ababa
Armed Forces General Hospital Addis Ababa
Goudsmit, Jaap
Netherlands, Leiden
Crucell nv
Berkhout, Ben
Netherlands, Amsterdam
Universiteit Van Amsterdam
Paxton, William A.
Netherlands, Amsterdam
Universiteit Van Amsterdam
DeBaar, Michel P.
Unknown Affiliation
Messele, Tsehaynesh
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Pollakis, Georgios P.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Statistics
Citations: 15
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.2174/1874613600903010019
e-ISSN:
18746136
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Ethiopia