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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Field efficacy of a new mosaic long-lasting mosquito net (PermaNet® 3.0) against pyrethroid-resistant malaria vectors: A multi centre study in Western and Central Africa
Malaria Journal, Volume 9, No. 1, Article 113, Year 2010
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Description
Background: Due to the spread of pyrethroid-resistance in malaria vectors in Africa, new strategies and tools are urgently needed to better control malaria transmission. The aim of this study was to evaluate the performances of a new mosaic long-lasting insecticidal net (LLIN), i.e. PermaNet® 3.0, against wild pyrethroid-resistant Anopheles gambiae s.l. in West and Central Africa. Methods. A multi centre experimental hut trial was conducted in Malanville (Benin), Vallée du Kou (Burkina Faso) and Pitoa (Cameroon) to investigate the exophily, blood feeding inhibition and mortality induced by PermaNet® 3.0 (i.e. a mosaic net containing piperonyl butoxide and deltamethrin on the roof) comparatively to the WHO recommended PermaNet® 2.0 (unwashed and washed 20-times) and a conventionally deltamethrin-treated net (CTN). Results: The personal protection and insecticidal activity of PermaNet 3.0 and PermaNet® 2.0 were excellent (>80%) in the "pyrethroid- tolerant" area of Malanville. In the pyrethroid-resistance areas of Pitoa (metabolic resistance) and Vallée du Kou (presence of the L1014F kdr mutation), PermaNet® 3.0 showed equal or better performances than PermaNet® 2.0. It should be noted however that the deltamethrin content on PermaNet® 3.0 was up to twice higher than that of PermaNet® 2.0. Significant reduction of efficacy of both LLIN was noted after 20 washes although PermaNet® 3.0 still fulfilled the WHO requirement for LLIN. Conclusion: The use of combination nets for malaria control offers promising prospects. However, further investigations are needed to demonstrate the benefits of using PermaNet® 3.0 for the control of pyrethroid resistant mosquito populations in Africa. © 2010Corbel et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2877060/bin/1475-2875-9-113-S1.DOC
https://efashare.b-cdn.net/share/pmc/articles/PMC2877060/bin/1475-2875-9-113-S2.DOC
https://efashare.b-cdn.net/share/pmc/articles/PMC2877060/bin/1475-2875-9-113-S3.DOC
Authors & Co-Authors
Corbel, Vincent
Benin
Institut de Recherche Pour le Développement Ird
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Chabi, Joseph
Benin
Institut de Recherche Pour le Développement Ird
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Dabiré, Roch Kounbobr
Burkina Faso, Ouagadougou
Centre Muraz
Etang, Josiane
Cameroon, Yaounde
Organisation de Coordination Pour la Lutte Contre Les Endémies en Afrique Centrale Cameroon
Nwane, Philippe Bienvenu
Cameroon, Yaounde
Organisation de Coordination Pour la Lutte Contre Les Endémies en Afrique Centrale Cameroon
Pigeon, Olivier
Belgium, Gembloux
Wallon Agricultural Research Centre
Akogbéto, Martin Codjo
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Hougard, Jean Marc
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Statistics
Citations: 115
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1186/1475-2875-9-113
e-ISSN:
14752875
Research Areas
Cancer
Infectious Diseases
Noncommunicable Diseases
Study Locations
Benin
Burkina Faso
Cameroon