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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan
Nature Communications, Volume 11, No. 1, Article 1536, Year 2020
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Description
The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes. © 2020, The Author(s).
Authors & Co-Authors
Day, Felix R.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Thompson, Deborah J.
United Kingdom, Cambridge
University of Cambridge
Soares, Ana Luiza Gonçalves
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Timmers, Paul R.H.J.
United Kingdom, Bristol
University of Bristol
United Kingdom, Edinburgh
The University of Edinburgh
Kwong, Alex Siu Fung
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Switzerland, Lausanne
Institut Universitaire de Médecine Sociale et Préventive Lausanne
United Kingdom, Bristol
University of Bristol
Easton, Douglas F.
United Kingdom, Cambridge
University of Cambridge
Joshi, Peter K.
United Kingdom, Bristol
University of Bristol
United Kingdom, Edinburgh
The University of Edinburgh
Timpson, Nicholas J.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Eeles, Rosalind A.
United Kingdom, London
The Institute of Cancer Research
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Henderson, Brian E.
United States, Los Angeles
Keck School of Medicine of Usc
Haiman, Christopher A.
United States, Los Angeles
Keck School of Medicine of Usc
Kóte-Jarai, Zsofia S.
United Kingdom, London
The Institute of Cancer Research
Schumacher, Fredrick R.
United States, Cleveland
Case Western Reserve University
United States, Cleveland
University Hospitals Case Medical Center
Al Olama, Ali Amin
United Kingdom, Cambridge
University of Cambridge
Benlloch, Sara
United Kingdom, London
The Institute of Cancer Research
United Kingdom, Cambridge
University of Cambridge
Muir, Kenneth Ross
United Kingdom, Manchester
The University of Manchester
United Kingdom, Coventry
University of Warwick
Berndt, Sonja I.
United States, Bethesda
National Institutes of Health Nih
Conti, David V.
United States, Los Angeles
Keck School of Medicine of Usc
Wiklund, Fredrik E.
Sweden, Stockholm
Karolinska Institutet
Chanock, Stephen J.
United States, Bethesda
National Institutes of Health Nih
Gapstur, Susan M.
United States, Kennesaw
American Cancer Society
Stevens, Victoria L.
United States, Kennesaw
American Cancer Society
Tangen, Catherine M.
United States, Seattle
Fred Hutchinson Cancer Center
Batra, Jyotsna
Australia, Brisbane
Australian Prostate Cancer Research Centre – Queensland
Australia, Woolloongabba
Translational Research Institute Australia
Clements, Judith Ann
Australia, Brisbane
Australian Prostate Cancer Research Centre – Queensland
Australia, Woolloongabba
Translational Research Institute Australia
Grönberg, Henrik
Sweden, Stockholm
Karolinska Institutet
Pashayan, Nora
United Kingdom, London
University College London
United Kingdom, Cambridge
University of Cambridge
Schleutker, Johanna
Finland, Turku
Turun Yliopisto
Finland, Turku
Turun Yliopistollinen Keskussairaala
Albanes, Demetrius
United States, Bethesda
National Institutes of Health Nih
Wolk, Alicja
Sweden, Stockholm
Karolinska Institutet
Sweden, Uppsala
Uppsala Universitet
West, Catharine Mary Louise
United Kingdom, Manchester
Health Innovation Manchester
Mucci, Lorelei Ann
United States, Boston
Harvard T.h. Chan School of Public Health
Cancel-Tassin, Géraldine
France, Paris
Hôpital Tenon
Koutros, Stella
United States, Bethesda
National Institutes of Health Nih
Sørensen, Karina Dalsgaard Dalsgaard
Denmark, Aarhus
Aarhus Universitetshospital
Denmark, Aarhus
Aarhus Universitet
Grindedal, Eli Marie
Norway, Oslo
Oslo Universitetssykehus
Neal, David E.
United Kingdom, Cambridge
Addenbrooke's Hospital
United Kingdom, Cambridge
Cancer Research uk Cambridge Institute
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
John Radcliffe Hospital
Hamdy, Freddie C.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
John Radcliffe Hospital
Donovan, Jenny L.
United Kingdom, Bristol
University of Bristol
Travis, Ruth C.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Hamilton, Robert James
Canada, Toronto
Princess Margaret Cancer Centre
Ingles, Sue Ann
United States, Los Angeles
Keck School of Medicine of Usc
Rosenstein, Barry S.
United States, New York
Icahn School of Medicine at Mount Sinai
Lu, Yongjie
United Kingdom, London
Queen Mary University of London
Giles, Graham G.
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Kibel, Adam S.
United States, Boston
Brigham and Women's Hospital
Vega, Ana Karina
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Kogevinas, Manolis
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Barcelona
Institut Municipal D'investigacio Medica
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Penney, Kathryn L.
United States, Boston
Harvard Medical School
Park, Jong-yun
United States, Tampa
Moffitt Cancer Center
Stanford, Janet L.
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Cybulski, Cezary
Poland, Szczecin
Pomeranian Medical University in Szczecin
Nordestgaard, BØrge Grønne
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Copenhagen University Hospital
Brenner, Hermann
Germany, Heidelberg
German Cancer Research Center
Maier, Christiane
Germany, Ulm
Universitätsklinikum Ulm
John, Esther M.
United States, Fremont
Cancer Prevention Institute of California
United States, Stanford
Stanford University School of Medicine
Teixeira, Manuel Rodrigues
Portugal, Porto
Instituto Português de Oncologia do Porto fg
Portugal, Porto
Universidade do Porto
Floris, Giuseppe L.
United States, Duarte
City of Hope National Med Center
de Ruyck, Kim
Belgium, Ghent
Universiteit Gent
Razack, Azad Hassan Abdul
Malaysia, Kuala Lumpur
Universiti Malaya
Newcomb, Lisa F.
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Lessel, Davor
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Kaneva, Radka
Bulgaria, Sofia
Medical University of Sofia
Usmani, Nawaid H.
Canada, Edmonton
Cross Cancer Institute
Claessens, Frank
Belgium, Leuven
Ku Leuven
Townsend, Paul A.
United Kingdom, Manchester
Health Innovation Manchester
Gago-Dominguez, Manuela
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
United States, La Jolla
University of California, San Diego
Roobol, Monique J.
Netherlands, Rotterdam
Erasmus Mc
Ménégaux, Florence
France, Paris
Inserm
Khaw, Kay Tee T.
United Kingdom, Cambridge
University of Cambridge
Cannon-Albright, Lisa Anne
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
Pandha, Hardev S.
United Kingdom, Guildford
University of Surrey
Thibodeau, Stephen N.
United States, Rochester
Mayo Clinic
Agee, Michelle
United States, Mountain View
23andme Inc.
Auton, Adam
United States, Mountain View
23andme Inc.
Bell, Robert K.
United States, Mountain View
23andme Inc.
Bryc, Katarzyna
United States, Mountain View
23andme Inc.
Elson, Sarah L.
United States, Mountain View
23andme Inc.
Fontanillas, Pierre
United States, Mountain View
23andme Inc.
Furlotte, Nicholas A.
United States, Mountain View
23andme Inc.
Hinds, David A.
United States, Mountain View
23andme Inc.
Huber, Karen E.
United States, Mountain View
23andme Inc.
Kleinman, Aaron
United States, Mountain View
23andme Inc.
Litterman, Nadia K.
United States, Mountain View
23andme Inc.
McIntyre, Matthew H.
United States, Mountain View
23andme Inc.
Mountain, Joanna L.
United States, Mountain View
23andme Inc.
Noblin, Elizabeth S.
United States, Mountain View
23andme Inc.
Northover, Carrie A.M.
United States, Mountain View
23andme Inc.
Pitts, Steven J.
United States, Mountain View
23andme Inc.
Sathirapongsasuti, Jarupon Fah
United States, Mountain View
23andme Inc.
Sazonova, Olga V.
United States, Mountain View
23andme Inc.
Shelton, Janie F.
United States, Mountain View
23andme Inc.
Shringarpure, Suyash S.
United States, Mountain View
23andme Inc.
Tian, Chao
United States, Mountain View
23andme Inc.
Tung, Joyce Y.
United States, Mountain View
23andme Inc.
Vacic, Vladimir
United States, Mountain View
23andme Inc.
Wilson, Catherine H.
United States, Mountain View
23andme Inc.
Ong, Ken K.L.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
United Kingdom, Cambridge
School of Clinical Medicine
Perry, John R.B.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Tilley, Wayne D.
Unknown Affiliation
Risbridger, Gail Petuna
Unknown Affiliation
Horvath, Lisa G.
Unknown Affiliation
Hayes, Vanessa M.
Unknown Affiliation
Haynes, Anne Maree
Unknown Affiliation
Kedda, Mary Anne
Unknown Affiliation
Moya, Leire
Unknown Affiliation
Statistics
Citations: 28
Authors: 106
Affiliations: 75
Identifiers
Doi:
10.1038/s41467-020-14451-5
ISSN:
20411723
Research Areas
Genetics And Genomics
Study Design
Randomised Control Trial
Participants Gender
Male
Female