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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
An international cohort study of birth outcomes associated with hospitalized acute respiratory infection during pregnancy
Journal of Infection, Volume 81, No. 1, Year 2020
Notification
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Description
Objectives: Findings during the 2009 pandemic suggest severe maternal infection with pandemic influenza had adverse perinatal health consequences. Limited data exist evaluating the perinatal health effects of severe seasonal influenza and non-influenza infections during pregnancy. Methods: A retrospective cohort of pregnant women from Australia, Canada, Israel, and the United States was established using birth records to identify pregnancies and birth outcomes and hospital and laboratory testing records to identify influenza and non-influenza associated acute respiratory or febrile illness (ARFI) hospitalizations. ARFI hospitalized women were matched to non-hospitalized women (1:4) by country and season of conception. Log-binomial regression was used to estimate the relative risk (aRR) of preterm birth (PTB), small-for-gestational-age (SGA), and low birthweight (LBW) birth, adjusting for pre-existing medical conditions, maternal age, and parity. Results: 950 pregnant women hospitalized with an ARFI were matched with 3,800 non-hospitalized pregnant women. Compared to non-hospitalized women, risk of PTB was greater among women hospitalized with influenza-associated ARFI (aRR: 1.57; 95% CI: 1.15–2.15) and non-influenza ARFI (aRR: 2.78; 95% CI: 2.12–3.65). Similar results were observed for LBW; there were no associations with SGA birth. Conclusions: ARFI hospitalization during pregnancy was associated with increased risk of PTB and LBW. © 2020
Authors & Co-Authors
Regan, Annette K.
United States, College Station
Texas A&m University
Australia, Perth
The Faculty of Health Sciences
Australia, Perth
Telethon Kids Institute
Azziz-Baumgartner, Eduardo
United States, Atlanta
Centers for Disease Control and Prevention
Williams, Jennifer L.
United States, Atlanta
Centers for Disease Control and Prevention
Effler, Paul V.
Unknown Affiliation
Katz, Mark A.
Israel, Tel Aviv-yafo
Clalit Health Services
Israel, Beer-sheva
Ben-gurion University of the Negev
United States, Ann Arbor
University of Michigan School of Public Health
Fink, Rebecca V.
United States, Cambridge
Abt Associates, Inc.
Thompson, Mark G.
United States, Atlanta
Centers for Disease Control and Prevention
Chung, Hannah
Canada, Toronto
Institute for Clinical Evaluative Sciences
Kwong, Jeff C.
Canada, Toronto
Institute for Clinical Evaluative Sciences
Fell, Deshayne Blayre
Canada, Toronto
Institute for Clinical Evaluative Sciences
Canada, Ottawa
University of Ottawa
Canada, Ottawa
Children's Hospital of Eastern Ontario, Ottawa
Statistics
Citations: 14
Authors: 10
Affiliations: 13
Identifiers
Doi:
10.1016/j.jinf.2020.03.057
ISSN:
01634453
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Female