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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Immune response to Bordetella pertussis is associated with season and undernutrition in Senegalese children
Vaccine, Volume 32, No. 27, Year 2014
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Description
Background: While vaccines elicit a protective response in most recipients, studies suggest that environmental and nutritional factors can influence the strength of the individual response to immunization and to subsequent natural infectious challenges. Methods: We conducted a longitudinal survey in Senegal to assess the individual response to B. pertussis, a respiratory disease against which Senegalese children are vaccinated before the age of one (Clinicaltrials.gov ID: NCT01545115). A cohort of 203 children aged 1-9 from four villages of the Senegal River Valley was followed-up for 14 months (October 2008-January 2010). During that period, four visits have been made to the villages to assess the immunological and nutritional status of these children and to determine risk factors involved in the modulation of their humoral immune response to B. pertussis toxin. Results: A multivariate model has demonstrated that birth season and nutritional status appeared to modulate humoral response to pertussis toxin. Moreover, response to B. pertussis was dependent on age, village and time of visit. Conclusions: These results are consistent with the hypothesis that environmental and nutritional factors modulate children's response to pertussis following natural infection or vaccination. © 2014 Elsevier Ltd.
Authors & Co-Authors
Gaayeb, Lobna
Senegal, Saint-louis
Epls Biomedical Research Center
France, Lille
Institut Pasteur de Lille
Pinçon, Claire
France, Lille
Université de Lille
Cames, Cécile
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Sarr, Jean B.
Senegal, Saint-louis
Epls Biomedical Research Center
Seck, Modou
Senegal, Saint-louis
Epls Biomedical Research Center
Schacht, Anne Marie
Senegal, Saint-louis
Epls Biomedical Research Center
France, Lille
Institut Pasteur de Lille
Remoué, Franck J.
France, Montpellier
Université de Montpellier
Hermann, Emmanuel
Senegal, Saint-louis
Epls Biomedical Research Center
France, Lille
Institut Pasteur de Lille
France, Lille
Université de Lille
Riveau, Gilles J.
Senegal, Saint-louis
Epls Biomedical Research Center
France, Lille
Institut Pasteur de Lille
Statistics
Citations: 20
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.vaccine.2014.03.086
ISSN:
0264410X
e-ISSN:
18732518
Research Areas
Food Security
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Senegal