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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Growth Rate of Plasmodium falciparum: Analysis of Parasite Growth Data from Malaria Volunteer Infection Studies
Journal of Infectious Diseases, Volume 221, No. 6, Year 2020
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Description
Background: Growth rate of malaria parasites in the blood of infected subjects is an important measure of efficacy of drugs and vaccines. Methods: We used log-linear and sine-wave models to estimate the parasite growth rate of the 3D7 strain of Plasmodium falciparum using data from 177 subjects from 14 induced blood stage malaria (IBSM) studies conducted at QIMR Berghofer. We estimated parasite multiplication rate per 48 hours (PMR48), PMR per life-cycle (PMRLC), and parasite life-cycle duration. We compared these parameters to those from studies conducted elsewhere with infections induced by IBSM (n=66), sporozoites via mosquito bite (n=336), or injection (n=51). Results: The parasite growth rate of 3D7 in QIMR Berghofer studies was 0.75/day (95% confidence interval [CI],. 73-.77/day), PMR48 was 31.9 (95% CI, 28.7-35.4), PMRLC was 16.4 (95% CI, 15.1-17.8), and parasite life-cycle was 38.8 hours (95% CI, 38.3-39.2 hours). These parameters were similar to estimates from IBSM studies elsewhere (0.71/day, 95% CI,. 67-.75/day; PMR48 26.6, 95% CI, 22.2-31.8) but significantly higher (P<.001) than in sporozoite studies (0.47/day, 95% CI,. 43-.50/day; PMR48 8.6, 95% CI, 7.3-10.1). Conclusions: Parasite growth rates were similar across different IBSM studies and higher than infections induced by sporozoite. © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
Authors & Co-Authors
Webb, Lachlan
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Mordmüller, Benjamin G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Murphy, Sean C.
United States, Seattle
University of Washington
Kublin, James G.
United States, Seattle
Fred Hutchinson Cancer Center
McCarthy, James S.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Australia, Brisbane
The University of Queensland
Marquart-Wilson, Louise
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Statistics
Citations: 16
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1093/infdis/jiz557
ISSN:
00221899
Research Areas
Infectious Diseases