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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chronic caloric restriction induces stress proteins in the hypothalamus of rats
Mechanisms of Ageing and Development, Volume 76, No. 1, Year 1994
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Description
The induction of stress proteins (sps) in the hypothalamus of female Fischer 344 rats in response to caloric restriction (CR) and to heat stress was investigated. Caloric restriction was found to elicit sps 27, 34, 70, and 90 in the hypothalamus of both young and old rats while none was found in the hypothalamus of ad libitum (AL) fed controls. Heat stress initiated heat shock proteins (hsps/sps) 27, 70, and 90 in the hypothalamus of the young (AL) fed animals, the same proteins evoked by feeding stress. The same sps were induced in the old (AL) rats although the expression showed substantial decline with age. This reduction was less marked, however, with the old CR rats. Stress protein 34, an infrequently reported protein, was related to feeding and was not induced by heat shock. Recent reports point to the important role sps play in the cellular reaction to stress, as well as their involvement in the higher functions. The findings reported here suggest that sps are involved in the regulatory mechanisms allowing CR animals to tolerate stress related to metabolic substrate deprivation. © 1994.
Authors & Co-Authors
Aly, Khaled B.
Egypt, Cairo
Faculty of Medicine
Pipkin, James L.
United States, Jeffersonville
National Center for Toxicological Research
United States, Little Rock
University of Arkansas for Medical Sciences
Hinson, William G.
United States, Jeffersonville
National Center for Toxicological Research
Feuers, Ritchie J.
United States, Jeffersonville
National Center for Toxicological Research
United States, Little Rock
University of Arkansas for Medical Sciences
Duffy, Peter H.
United States, Jeffersonville
National Center for Toxicological Research
Lyn-Cook, L. E.
United States, Jeffersonville
National Center for Toxicological Research
Hart, Ronald W.
United States, Jeffersonville
National Center for Toxicological Research
Statistics
Citations: 68
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/0047-6374(94)90003-5
ISSN:
00476374
Research Areas
Noncommunicable Diseases
Participants Gender
Female