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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Pathologic studies on suspect animal and human cases of Rift Valley fever from an outbreak in Eastern Africa, 2006-2007
American Journal of Tropical Medicine and Hygiene, Volume 83, No. 2 SUPPL., Year 2010
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Description
Rift Valley fever (RVF) is an important viral zoonotic disease in Africa with periodic outbreaks associated with severe disease, death, and economic hardship. During the 2006-2007 outbreaks in Eastern Africa, postmortem and necropsy tissue samples from 14 animals and 20 humans clinically suspected of RVF were studied with histopathologic evaluation and immunohistochemical (IHC) assays. Six animal and 11 human samples had IHC evidence of Rift Valley fever virus (RVFV) antigens. We found that extensive hepatocellular necrosis without prominent inflammatory cell infiltrates is the most distinctive histopathologic change in liver tissues infected with RVFV Pathologic studies on postmortem tissue samples can help establish the diagnosis of RVF, differentiating from endemic diseases with clinical manifestations similar to RVF, such as malaria, leptospirosis, or yellow fever. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Shieh, Wun Ju
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Paddock, Christopher D.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Lederman, Edith R.
United States, San Diego
Naval Medical Center San Diego
Rao, C. Y.
United States, Atlanta
National Center for Preparedness, Detection, and Control of Infectious Diseases
Gould, L. Hannah
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Mohamed, Mohamed Ally
Tanzania, Dar es Salaam
Ministry of Health and Social Welfare
Mosha, Fausta Shakiwa
Tanzania, Dar es Salaam
Tanzania Field Epidemiology and Laboratory Training Program
Mghamba, Janneth Maridadi
Tanzania, Dar es Salaam
Ministry of Health and Social Welfare
Bloland, Peter Brian
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Njenga, Moses Kariuki
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Mutonga, David M.
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Amwayi, Samuel Anyangu
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Guarner, Jeannette
United States, Atlanta
Emory University Hospital
Breiman, Robert F.
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Zaki, Sherif R.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Statistics
Citations: 52
Authors: 15
Affiliations: 8
Identifiers
Doi:
10.4269/ajtmh.2010.09-0463
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases