Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Effects on duration of post-operative ischemia and patterns of blood flow recovery in different conditions of mouse hind limb ischemia
Vascular Cell, Volume 3, Article 14, Year 2011
Notification
URL copied to clipboard!
Description
Background: Current limitations to the experimentation on patients with peripheral arterial disease push the development of different preclinical strategies. We investigated both duration of ischemia and blood flow recovery in mouse models of partial femoral artery ligation. Methods. Male BALB/c mice were used. The ligation over needle method involved placing a suture needle over the femoral artery, ligating over it and then removing the needle. The transfixation method involved transfixing the approximate center of the femoral artery and then tying the suture. Laser Doppler Perfusion Imaging was used to assess perfusion every 3 rd day until 42 days after the procedure. Results: Ligation over needle method: Immediately post procedure, mean perfusion was -71.87% 4.43. Then mean difference in perfusion remained below the base line reading on days 3, 6, 9, and 12. From day 15 on wards mean perfusion progressively improved remaining near base line. Transfixation Method: Immediately post procedure mean perfusion was -70.82% 4.73. Mean perfusion improved following the procedure on days 3 and 6; a plateau followed this on days 9, 12 and 15. From day 15 onwards perfusion progressively improved remaining well below base line until crossing it on day 36. Conclusion: The currently described models do not pose major improvements over previously described methods. © 2011 Al-Mubarak et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Al-Mubarak, Husain A.
Saudi Arabia, Riyadh
College of Medicine
Canada, Toronto
Li ka Shing Knowledge Institute
Alamri, Talal M.
Saudi Arabia, Riyadh
College of Medicine
Canada, Toronto
Li ka Shing Knowledge Institute
Aljabab, S.
Saudi Arabia, Riyadh
College of Medicine
Canada, Toronto
Li ka Shing Knowledge Institute
Atteya, Muhammad
Saudi Arabia, Riyadh
College of Medicine
Quan, Adrian
Canada, Toronto
Li ka Shing Knowledge Institute
Teoh, Hwee
Canada, Toronto
Li ka Shing Knowledge Institute
Shukla, Praphulla C.
Canada, Toronto
Li ka Shing Knowledge Institute
Verma, Subodh G.
Canada, Toronto
Li ka Shing Knowledge Institute
Aldahmash, Abdullah M.
Saudi Arabia, Riyadh
College of Medicine
Canada, Toronto
Li ka Shing Knowledge Institute
Aljabri, Badr A.
Saudi Arabia, Riyadh
College of Medicine
Canada, Toronto
Li ka Shing Knowledge Institute
Napoli, Claudio
Saudi Arabia, Riyadh
College of Medicine
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Al-Omran, Mohammed A.
Saudi Arabia, Riyadh
College of Medicine
Canada, Toronto
Li ka Shing Knowledge Institute
Statistics
Citations: 12
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1186/2045-824X-3-14
e-ISSN:
2045824X
Participants Gender
Male