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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Different low doses of broad-band UVA in the treatment of morphea and systemic sclerosis. A clinico-pathologic study
Photodermatology Photoimmunology and Photomedicine, Volume 20, No. 3, Year 2004
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Description
Background: Numerous treatment modalities, some with potentially hazardous side effects, are currently used for morphea (M) and systemic sclerosis (SS) with limited success. Low-dose ultraviolet A (UVA) phototherapy (20 J/cm2) was found to be highly effective for sclerotic patches, even in patients with advanced and rapidly evolving lesions. Objective: To determine the effectiveness of different low doses of UVA in treating patients with M and SS. Methods: Sixty-three patients complaining of M and 15 patients complaining of SS received 20 sessions of UVA (320-400 nm) each. Patients were divided randomly into three groups that received 5, 10 and 20 J/cm2, with cumulative UVA doses of 100, 200, and 400 J/cm2 , respectively. The efficacy of therapy was judged clinically (by sequential inspection and palpation) and histopathologically by morphometry in M cases. Results: Obvious clinical improvement, with no comparable differences between various low UVA doses, was noted in patients with M and SS, accompanied by histopathological changes towards normalization of collagen. Conclusions: After 20 sessions, it appears that lower doses of UVA (5, 10 J/cm2) are as beneficial as the relatively higher dose (20 J/cm2) in the treatment of M and SS. Copyright © Blackwell Munksgaard 2004.
Authors & Co-Authors
El-Mofty, Medhat A.
Egypt, Cairo
Faculty of Medicine
Mostafa, Wedad Z.
Egypt, Cairo
Faculty of Medicine
EL DAROUTI, MOHAMED A.
Egypt, Cairo
Faculty of Medicine
Bosseila, Manal A.W.
Egypt, Cairo
Faculty of Medicine
Nada, Hanan Rabea
Egypt, Cairo
Faculty of Medicine
Yousef, Randa M.
Egypt, Cairo
Faculty of Medicine
Esmat, Samia M.
Egypt, Cairo
Faculty of Medicine
El-Lawindi, Mona Ibrahim
Egypt, Cairo
Faculty of Medicine
Assaf, Magda I.
Egypt, Zagazig
Zagazig University, Faculty of Medicine
El-Enani, G.
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 73
Authors: 10
Affiliations: 2
Identifiers
Doi:
10.1111/j.1600-0781.2004.00081.x
ISSN:
09054383