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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India
Virology, Volume 385, No. 2, Year 2009
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Description
Little is known about the neutralization properties of HIV-1 in India to optimally design and test vaccines. For this reason, a functional Env clone was obtained from each of ten newly acquired, heterosexually transmitted HIV-1 infections in Pune, Maharashtra. These clones formed a phylogenetically distinct genetic lineage within subtype C. As Env-pseudotyped viruses the clones were mostly resistant to IgG1b12, 2G12 and 2F5 but all were sensitive to 4E10. When compared to a large multi-subtype panel of Env-pseudotyped viruses (subtypes B, C and CRF02_AG) in neutralization assays with a multi-subtype panel of HIV-1-positive plasma samples, the Indian Envs were remarkably complex. With the exception of the Indian Envs, results of a hierarchical clustering analysis showed a strong subtype association with the patterns of neutralization susceptibility. From these patterns we were able to identify 19 neutralization cluster-associated amino acid signatures in gp120 and 14 signatures in the ectodomain and cytoplasmic tail of gp41. We conclude that newly transmitted Indian Envs are antigenically complex in spite of close genetic similarity. Delineation of neutralization-associated amino acid signatures provides a deeper understanding of the antigenic structure of HIV-1 Env. © 2008 Elsevier Inc.
Authors & Co-Authors
Kulkarni, Smita S.
India, Pune
National Aids Research Institute India
Lapedes, Alan
United States, Los Alamos
Los Alamos National Laboratory
Tang, Haili
United States, Durham
Duke University Medical Center
Gnanakaran, Sandrasegaram
United States, Los Alamos
Los Alamos National Laboratory
Daniels, Marcus G.
United States, Los Alamos
Los Alamos National Laboratory
Zhang, Ming
United States, Los Alamos
Los Alamos National Laboratory
Bhattacharya, Tanmoy
United States, Los Alamos
Los Alamos National Laboratory
Li, Ming
United States, Durham
Duke University Medical Center
Polonis, Victoria R.
United States, Rockville
Hjf
McCutchan, Francine E.
United States, Rockville
Hjf
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Ellenberger, Dennis L.
United States, Atlanta
Centers for Disease Control and Prevention
Butera, Salvatore T.
United States, Atlanta
Centers for Disease Control and Prevention
Bollinger, Robert Cyril
United States, Baltimore
Johns Hopkins School of Medicine
Korber, Bette T.
United States, Los Alamos
Los Alamos National Laboratory
Paranjape, Ramesh S.
India, Pune
National Aids Research Institute India
Montefiori, David Charles
United States, Durham
Duke University Medical Center
Statistics
Citations: 17
Authors: 17
Affiliations: 7
Identifiers
Doi:
10.1016/j.virol.2008.12.032
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Genetics And Genomics
Infectious Diseases