Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The peroxisome proliterator activated receptorγ
2
(PPARγ
2
) Pro12Ala variant: Lack of association with type 2 diabetes in obese and non obese Tunisian patients
Diabetes and Metabolism, Volume 31, No. 2, Year 2005
Notification
URL copied to clipboard!
Description
Objectives: Peroxisome proliferator activated receptorγ2 (PPARγ2) is a nuclear receptor that regulates adipocyte differentiation, lipid metabolism and probably insulin sensitivity. There have been several reports on the relationship between the PPARγ2 Pro12Ala genotype and the development of obesity or type 2 diabetes. We designed a case-controlled study to investigate the potential association of the genetic variation of the PPARγ2 gene with type 2 diabetes in Tunisians. Methods: We used the polymerase chain reaction and restriction enzyme digestion to characterize the variation of the Pro12Ala polymorphism of the PPARγ2 gene in 242 unrelated Tunisian patients with type 2 diabetes and 246 healthy control subjects. Results: Analysis of the Pro12Ala polymorphism of the PPARγ2 gene in patients with type 2 diabetes and in control subjects revealed no significant differences in the PPARγ2 allele frequencies between diabetic patients and control subjects. However the PPARγ2 Ala12 allele was found significantly associated with a high level of systolic blood pressure in diabetic patients. Stratification of diabetic patients on obese and non obese subjects showed non significant differences in the PPARγ2 Ala12 frequency between the two groups. Conclusion: These results suggest that the PPARγ2 gene is unlikely a major gene for type 2 diabetes mellitus or obesity in Tunisian subjects. © 2005 Masson, all rights reserved.
Authors & Co-Authors
Bouassida, K. Zouari
Tunisia, Tunis
Institut National de Nutrition & Technologie Alimentaire
Chouchane, Lotfi
Tunisia, Monastir
Faculty of Medicine
Jellouli, Kamel
Tunisia, Tunis
Institut National de Nutrition & Technologie Alimentaire
Chérit, S.
Tunisia, Tunis
Institut National de Nutrition & Technologie Alimentaire
Haddad, Samira
Tunisia, Tunis
Institut National de Nutrition & Technologie Alimentaire
Gabbouj, Sallouha
Tunisia, Monastir
Faculty of Medicine
Danguir, Jaber
Tunisia, Tunis
Institut National de Nutrition & Technologie Alimentaire
Statistics
Citations: 28
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1016/s1262-3636(07)70177-5
ISSN:
12623636
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases