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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of once-a-day fractionated total body irradiation on the risk of relapse after non-T-cell-depleted HLA-matched sibling transplantation
Radiation Medicine - Medical Imaging and Radiation Oncology, Volume 25, No. 8, Year 2007
Notification
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Description
Purpose. The aim of this study was to assess the impact of fractionated total body irradiation (F-TBI) on treatment-related mortality (TRM) and relapse in patients who received a non-T-cell-depleted allogeneic stem cell transplantation (ASCT) for hematological malignancies. Materials and methods. Between March 2003 and December 2004, a total of 24 patients with HLA-identical sibling donors entered this study and received three doses of 3.33 Gy F-TBI separated by 24 h and cyclophosphamide or etoposide. Results. At a median follow-up of 37 months (range 29-47 months), 4 of the 24 patients (16.6%) died of TRM. Relapse occurred in 10 patients at a median of 9 months (range 2-18 months). Overall, 13 of 24 patients (54%) died. Relapse was the most common cause of death (9/13). The 2-year actuarial survival rate was 46% (±11%). Conclusion. In our experience, ASCT conditioned with F-TBI was associated with low TRM but a high early relapse rate in patients with hematological malignancies. © 2007 Japan Radiological Society.
Authors & Co-Authors
Othman, Tarek Ben
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Kochbati, Lotfi
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Abdelkefi, Abderrahman
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Ladeb, Saloua
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Torjman, Lamia
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Lakhal, Amel
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Kammoun, Leïla
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Hentati, Dalenda
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Besbes, Mounir
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Abdeladhim, Abdeladhim Ben
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Maâlej, Mongi
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Statistics
Citations: 11
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1007/s11604-007-0158-y
ISSN:
02882043
e-ISSN:
18625274
Study Design
Cohort Study