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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HIV-associated neurocognitive disorders in sub-Saharan Africa: A pilot study in Cameroon
BMC Neurology, Volume 10, Article 60, Year 2010
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Description
Background: The disease burden of human immunodeficiency virus (HIV) - acquired immunodeficiency syndrome (AIDS) is highest in sub-Saharan Africa but there are few studies on the associated neurocognitive disorders in this region. The objectives of this study were to determine whether Western neuropsychological (NP) methods are appropriate for use in Cameroon, and to evaluate cognitive function in a sample of HIV-infected adults.Methods: We used a battery of 19 NP measures in a cross-sectional study with 44 HIV+ adults and 44 demographically matched HIV- controls, to explore the validity of these NP measures in Cameroon, and evaluate the effect of viral infection on seven cognitive ability domains.Results: In this pilot study, the global mean z-score on the NP battery showed worse overall cognition in the HIV+ individuals. Significantly lower performance was seen in the HIV+ sample on tests of executive function, speed of information processing, working memory, and psychomotor speed. HIV+ participants with AIDS performed worse than those with less advanced HIV disease.Conclusions: Similar to findings in Western cohorts, our results in Cameroon suggest that HIV infection, particularly in advanced stages, is associated with worse performance on standardized, Western neurocognitive tests. The tests used here appear to be promising for studying NeuroAIDS in sub-Saharan Africa. © 2010 Kanmogne et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Kanmogne, Georgette D.
United States, Omaha
University of Nebraska Medical Center
Kuate-Tegueu, Callixte
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Cysique, Lucette
United States, La Jolla
University of California, San Diego
Australia, Sydney
Unsw Sydney
Fonsah, Julius Yundze
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Eta, Sabine
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Doh, Roland F.
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Njamnshi, Dora Mugha
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Nchindap, Emilienne
Cameroon, Yaounde
University Center Hospital
Franklin, Donald R.
United States, La Jolla
University of California, San Diego
Ellis, Ronald J.
United States, La Jolla
University of California, San Diego
McCutchan, John Allen
United States, La Jolla
University of California, San Diego
Binam, Fidéle
Cameroon, Yaounde
Université de Yaoundé I
Mbanya, Dora Ngum Shu
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
University Center Hospital
Heaton, Robert K.
United States, La Jolla
University of California, San Diego
Njamnshi, Alfred Kongnyu
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Statistics
Citations: 82
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1186/1471-2377-10-60
e-ISSN:
14712377
Research Areas
Infectious Diseases
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Cameroon