Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
The Wolbachia genome of Brugia malayi: Endosymbiont evolution within a human pathogenic nematode
PLoS Biology, Volume 3, No. 4, Year 2005
Notification
URL copied to clipboard!
Description
Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even more degraded than those of closely related Rickettsia species, Wolbachia has retained more intact metabolic pathways. The ability to provide riboflavin, flavin adenine dinucleotide, heme, and nucleotides is likely to be Wolbachia's principal contribution to the mutualistic relationship, whereas the host nematode likely supplies amino acids required for Wolbachia growth. Genome comparison of the Wolbachia endosymbiont of B. malayi (wBm) with the Wolbachia endosymbiont of Drosophila melanogaster (wMel) shows that they share similar metabolic trends, although their genomes show a high degree of genome shuffling. In contrast to wMel, wBm contains no prophage and has a reduced level of repeated DNA. Both Wolbachia have lost a considerable number of membrane biogenesis genes that apparently make them unable to synthesize lipid A, the usual component of proteobacterial membranes. However, differences in their peptidoglycan structures may reflect the mutualistic lifestyle of wBm in contrast to the parasitic lifestyle of wMel. The smaller genome size of wBm, relative to wMel, may reflect the loss of genes required for infecting host cells and avoiding host defense systems. Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosymbiont evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease. © 2005 Foster et al.
Authors & Co-Authors
Foster, Jeremy M.
United States, Ipswich
New England Biolabs
Ganatra, Mehul B.
United States, Ipswich
New England Biolabs
Kamal, I. H.
United States, Ipswich
New England Biolabs
Egypt, Cairo
College of Science
Ware, Jennifer
United States, Ipswich
New England Biolabs
Makarova, Kira S.
United States, Bethesda
National Library of Medicine Nlm
Ivanova, Natalia N.
United States, Chicago
Integrated Genomics
United States, Berkeley
U.s. Department of Energy Joint Genome Institute
Bhattacharyya, Anamitra
United States, Chicago
Integrated Genomics
Kapatral, Vinayak
United States, Chicago
Integrated Genomics
Kumar, Sanjay
United States, Ipswich
New England Biolabs
Posfai, Janos
United States, Ipswich
New England Biolabs
Vincze, Tamas
United States, Ipswich
New England Biolabs
Ingram, Jessica
United States, Ipswich
New England Biolabs
Moran, Laurie
United States, Ipswich
New England Biolabs
Lapidus, Alla L.
United States, Chicago
Integrated Genomics
United States, Berkeley
U.s. Department of Energy Joint Genome Institute
Omelchenko, Marina
United States, Bethesda
National Library of Medicine Nlm
Kyrpides, Nikos C.
United States, Chicago
Integrated Genomics
United States, Berkeley
U.s. Department of Energy Joint Genome Institute
Ghedin, Elodie
United States, Rockville
J. Craig Venter Institute
Wang, Shiliang
United States, Rockville
J. Craig Venter Institute
Goltsman, Eugene
United States, Chicago
Integrated Genomics
United States, Berkeley
U.s. Department of Energy Joint Genome Institute
Joukov, Victor
United States, Chicago
Integrated Genomics
Ostrovskaya, Olga
United States, Chicago
Integrated Genomics
United States, Cleveland
Case Western Reserve University
Tsukerman, Kiryl
United States, Chicago
Integrated Genomics
Mazur, Mikhail
United States, Chicago
Integrated Genomics
Comb, Donald
United States, Ipswich
New England Biolabs
Koonin, Eugene V.
United States, Bethesda
National Library of Medicine Nlm
Slatko, Barton E.
United States, Ipswich
New England Biolabs
Statistics
Citations: 601
Authors: 26
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pbio.0030121
ISSN:
15449173
e-ISSN:
15457885
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases
Sexual And Reproductive Health