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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Long-term assessment and serial evaluation of cardiorespiratory exercise performance and cardiac function in patients with atrial switch operation for complete transposition
Cardiology in the Young, Volume 11, No. 1, Year 2001
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Description
Background: At present, a considerable number of patients survive who underwent an atrial switch operation for correction of complete transposition. Our study aimed to assess their long-term exercise performance and the serial evolution of cardiac function. Methods: We studied 22 patients 5 to 17 years after an atrial switch operation, and followed them serially for 3.5 ± 2 years after the first evaluation. Cardiorespiratory exercise function was assessed by analysis of gas exhange and by determination of the ventilatory anaerobic threshold. Echocardiography was performed on all evaluations. Results: All patients were in Class I of the classification of the New York Heart Association at all assessments. Ventilatory anaerobic threshold, however, was significantly lower than normal. It averaged 77.9% ± 13.7 of the normal mean value at the initial evaluation, and remained stable when re-evaluated later (76.2 ± 13.7%). At the initial study, the increase in oxygen uptake during graded exercise was below the 95% confidence limit in 6 of the patients, and was below this level in 10 patients at re-assessment. The subnormal values for oxygen uptake during submaximal exercise were associated with moderate to severe haemodynamic dysfunction. At echocardiography, 15 of 17 patients studied twice had mild to moderate right ventricular dilation and tricuspidregurgiation, which remained virtually the same at reasssesment. A stable sinus rhythm was initially present in 17 patients, and persisted in 15 patients during follow-up. Conclusion: At medium term follow-up, cardiorespiratory exercise performance remains stable in patients after atrial switch repair. Serial exercise testing appears useful, because in individual patients in the present study, a decreasing exercise tolerance correlated with development of haemodynamic sequels. © Greenwich Medical Media Ltd.
Authors & Co-Authors
Reybrouck, Tony M.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Belgium, Leuven
Ku Leuven
Mertens, Luc L.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Brown, Stephen C.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Eyskens, Bénédicte
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Daenen, Willem J.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Gewillig, Marc H.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Statistics
Citations: 9
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1017/S1047951100012373
ISSN:
10479511
Research Areas
Noncommunicable Diseases
Study Design
Cohort Study