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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Microbiology of neonatal septicemia in a tertiary hospital in Benin City, Nigeria
Biomarkers and Genomic Medicine, Volume 5, No. 4, Year 2013
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Description
Septicemia is a major cause of death in neonates. Prompt diagnosis and effective treatment is necessary to treat patients with septicemia. However, the prevalence, etiology, and antibiotic susceptibility vary with location and time. This study aimed at determining the prevalence of neonatal septicemia and the effect of age and gender on this prevalence. In addition, the antibacterial susceptibility of etiologic agents was also determined. Blood samples were collected from 534 neonates (322 males and 212 females) between 1 day and 28 days of age with signs and symptoms of septicemia. The blood samples were processed to diagnose septicemia. Identification of bacterial isolates and disc susceptibility testing were performed using standard techniques. Age and gender did not significantly affect the prevalence of neonatal septicemia ( p=0.554 and 0.127, respectively). Klebsiella species were the predominant microorganism causing neonatal septicemia, in males and within the first 14 days of life. Fluoroquinolones, gentamicin, and β-lactams (with the exception of cloxacillin) were the most active antibacterial agents. An overall neonatal septicemia prevalence rate of 38.95% was observed. Klebsiella species was the most predominant isolate causing neonatal septicaemia. The β-lactam antibiotics recommended in susceptibility testing and the data collected in this study will be helpful in empiric therapy of neonatal septicemia. © 2013 .
Authors & Co-Authors
Omoregie, Richard
Benin, Benin
University of Benin Teaching Hospital
Egbe, Christopher Aye
Benin, Benin
University of Benin Teaching Hospital
Dirisu, John Osilume
Benin, Benin
University of Benin Teaching Hospital
Ogefere, Helen Oroboghae
Benin, Cotonou
University of Abomey-calavi
Statistics
Citations: 17
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.bgm.2013.06.001
ISSN:
22140247
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Benin
Nigeria
Participants Gender
Female