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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Long–term survival in trial of medium–titre Edmonston–Zagreb measles vaccine in Guinea–Bissau: Five–year follow–up
Epidemiology and Infection, Volume 112, No. 2, Year 1994
Notification
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Description
A trial of protective efficacy which compared medium–titre Edmonston-Zagreb (EZ) measles vaccine (104.6 p.f.u.) from the age of 4 months with the standard Schwarz (SW) measles vaccine given from the age of 9 months was started in an urban community in Guinea-Bissau in 1985. Because trials of high–titre measles vaccine have found increased mortality among female recipients, we examined whether EZ medium–titre vaccine was associated with any long-term impact on mortality, suppression of T–cells, or growth. The mortality rate ratio over 5 years of follow–up was 1.12 for EZ children compared with children in the standard group (P = 0.63). Seventy–five percent of the children still residing in the area at 5 years of age took part in an immunological and anthropometric examination. There was no difference in T–cell subsets between the two groups. There was no difference in mid–upper–arm circumference, but EZ children were significantly shorter than the children in the standard group. In conclusion, medium–titre EZ was not associated with reduced survival or persistent immunosuppression. © 1994, Cambridge University Press. All rights reserved.
Authors & Co-Authors
Aaby, Peter
Denmark, Copenhagen
Epidemiology Research Unit
Lisse, Ida Maria
Denmark, Hvidovre
Hvidovre Hospital
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Knudsen, Kim Mark
Denmark, Copenhagen
Epidemiology Research Unit
Thaarup, Jesper
Denmark, Copenhagen
International Medical Cooperation Committee
Poulsen, Anja Grethe
Denmark, Copenhagen
International Medical Cooperation Committee
Sodemann, Morten
Denmark, Copenhagen
International Medical Cooperation Committee
Jakobsen, Marianne Skytte
Denmark, Copenhagen
International Medical Cooperation Committee
Brink, Lene
Denmark, Copenhagen
International Medical Cooperation Committee
Gansted, Uffe
Denmark, Copenhagen
International Medical Cooperation Committee
Permin, Astrid
Denmark, Copenhagen
International Medical Cooperation Committee
Jensen, Thøger Gorm
Denmark, Copenhagen
International Medical Cooperation Committee
Andersen, Henning
Unknown Affiliation
da Silva, Maria Clotilde
Guinea-bissau, Health
Ministry of Public
Statistics
Citations: 15
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1017/S0950268800057836
ISSN:
09502688
e-ISSN:
14694409
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Guinea
Guinea-Bissau
Participants Gender
Female