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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Morbidity from malaria and immune responses to defined plasmodium falciparum antigens in children with sickle cell trait in the gambia
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 86, No. 5, Year 1992
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Description
Morbidity from Plasmodium falciparum malaria and humoral and in vitro cellular immune responses to defined malaria antigens were measured in rural Gambian children with haemoglobin phenotype AS (HbAS) and in those with a normal haemoglobin (HbAA). In a survey undertaken during the dry season, HbAS children had a higher parasite rate than HbAA children but a lower prevalence of parasitaemia at a level of 500/µl or greater. Malariometric indices measured during a rainy season survey were similar in the 2 groups of children. During the rainy season, the incidence of infection with P. falciparum did not vary with haemoglobin phenotype. However, in children aged 6 years or less, a significantly smaller proportion of HbAS children who acquired infection developed clinical symptoms than did HbAA children. During both the dry season and rainy season surveys, humoral and in vitro cellular immune responses to defined antigens from the sporozoite and merozoite stages of P. falciparum were similar in the 2 groups of children. Thus, despite the differences in parasite indices and morbidity from malaria between the 2 groups of children, we found no evidence of an enhanced immune response to malaria infection amongst HbAS children compared with normal children. © 1992 Oxford university press.
Authors & Co-Authors
Allen, Stephen John
Unknown Affiliation
Bennett, Stephen
Unknown Affiliation
Riley, Eleanor M.
Unknown Affiliation
Rowe, Pamela A.
Unknown Affiliation
Jakobsen, Palle Høy
Unknown Affiliation
O’Donnell, A.
Unknown Affiliation
Greenwood, Brian M.
Unknown Affiliation
Statistics
Citations: 79
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/0035-9203(92)90083-O
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Gambia