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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Anti-plasmodial Effects of Zanthoxylum zanthoxyloides
Planta Medica, Volume 85, No. 13, Year 2019
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Description
Zanthoxylum zanthoxyloides, syn. Fagara zanthoxyloides, is a tree growing in West Africa and is used in traditional medicine against a variety of diseases, including malaria. In the work reported here, root bark and stem bark extracts of this tree, as well as compounds isolated from the extracts, have been investigated for activity in vitro against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. In addition, toxicity against nauplii of the brine shrimp Artemia salina has been studied. Dichloromethane extracts of the root bark and stem bark, and a methanol extract of the stem bark, showed anti-parasitic activity towards chloroquine-sensitive as well as chloroquine-resistant P. falciparum, with IC 50 values between 1 and 10 μg/mL. Among the isolated compounds, bis-dihydrochelerythrinyl ether, buesgenine, chelerythrine, γ -fagarine, skimmianine, and pellitorine were the most active, with IC 50 values of less than 5 μg/mL. The dichloromethane extracts were toxic to brine shrimp nauplii, with LC 50 values of less than 1 μg/mL. Methanol extracts were much less toxic (LC 50 between 50 and 100 μg/mL). Among the isolated substances, bis-dihydrochelethrinyl ether was the most toxic (LC 50 ca. 2 μg/mL). © Georg Thieme Verlag KG Stuttgart.
Authors & Co-Authors
Goodman, Christopher Dean
Australia, Melbourne
University of Melbourne
Diallo, Drissa
Unknown Affiliation
Malterud, Karl Egil
Norway, Oslo
Universitetet I Oslo
McFadden, Geoffrey Ian
Australia, Melbourne
University of Melbourne
Wangensteen, Helle
Norway, Oslo
Universitetet I Oslo
Statistics
Citations: 16
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1055/a-0973-0067
ISSN:
00320943
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Study Locations
Multi-countries