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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus
Journal of Virology, Volume 82, No. 17, Year 2008
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Description
Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses and may favor the emergence of cVDPVs. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Riquet, Franck
France, Paris
Institut Pasteur, Paris
Blanchard, Claire
France, Paris
Institut Pasteur, Paris
Jegouic, Sophie
France, Paris
Institut Pasteur, Paris
Balanant, Jean G.
France, Paris
Institut Pasteur, Paris
Guillot, Sophie
France, Paris
Institut Pasteur, Paris
Vibet, Marie Anne
France, Paris
Institut Pasteur, Paris
Rakoto-Andrianarivelo, Mala
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Delpeyroux, Francis
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 8
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1128/JVI.00239-08
ISSN:
0022538X
Research Areas
Health System And Policy
Study Locations
Madagascar