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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Wherever i may roam: Protein and membrane trafficking in P. falciparum-infected red blood cells
Molecular and Biochemical Parasitology, Volume 186, No. 2, Year 2012
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Description
Quite aside from its immense importance as a human pathogen, studies in recent years have brought to light the fact that the malaria parasite Plasmodium falciparum is an interesting eukaryotic model system to study protein trafficking. Studying parasite cell biology often reveals an overrepresentation of atypical cell biological features, possibly driven by the parasites' need to survive in an unusual biological niche. Malaria parasites possess uncommon cellular compartments to which protein traffic must be directed, including secretory organelles such as rhoptries and micronemes, a lysosome-like compartment referred to as the digestive vacuole and a complex (four membrane-bound) plastid, the apicoplast. In addition, the parasite must provide proteins to extracellular compartments and structures including the parasitophorous vacuole, the parasitophorous vacuolar membrane, the Maurer's clefts and both cytosol and plasma membrane of the host cell, the mature human red blood cell. Although some of these unusual destinations are possessed by other cell types, only Plasmodium parasites contain them all within one cell. Here we review what is known about protein and membrane transport in the P. falciparum-infected cell, highlighting novel features of these processes. A growing body of evidence suggests that this parasite is a real "box of tricks" with regards to protein traffic. Possibly, these tricks may be turned against the parasite by exploiting them as novel therapeutic targets. © 2012 Elsevier B.V.
Authors & Co-Authors
Deponte, Marcel
Germany, Heidelberg
Universitätsklinikum Heidelberg
Hoppe, Heinrich C.
South Africa, Grahamstown
Rhodes University
Lee, Marcus Chee San
United States, New York
Columbia University
Maier, Alexander Gerd
Australia, Canberra
Anu Research School of Biology
Richard, Dave
Canada, Quebec
Université Laval
Rug, Melanie
Australia, Canberra
The Australian National University
Spielmann, Tobias
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Przyborski, Jude Marek
Germany, Marburg
Philipps-universität Marburg
Statistics
Citations: 63
Authors: 8
Affiliations: 8
Identifiers
Doi:
10.1016/j.molbiopara.2012.09.007
ISSN:
01666851
e-ISSN:
18729428
Research Areas
Infectious Diseases