Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
No association between Angiotensin Converting Enzyme (ACE) gene variation and endurance athlete status in Kenyans
Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, Volume 141, No. 2, Year 2005
Notification
URL copied to clipboard!
Description
East African runners are continually successful in international distance running. The extent to which genetic factors influence this phenomenon is unknown. The insertion (I) rather than deletion (D) of a 287 bp fragment in the human angiotensin converting enzyme (ACE) gene is associated with lower circulating and tissue ACE activity and with endurance performance amongst Caucasians. To assess the association between ACE gene variation and elite endurance athlete status in an African population successful in distance running, DNA samples were obtained from 221 national Kenyan athletes (N), 70 international Kenyan athletes (I), and 85 members of the general Kenyan population (C). Blood samples were obtained from C and assayed for circulating ACE activity. ACE I/D (rs????-from NCBI SNPdb first time poly mentioned) genotype was determined, as was genotype at A22982GD (rs????-from NCBI SNPdb first time poly mentioned) which has been shown to associate more closely with ACE levels in African subjects than the I/D polymorphism. ACE I/D and A22982G genotypes explained 13 and 24% of variation in circulating ACE activity levels (P = 0.034 and < 0.001 respectively). I/D genotype was not associated with elite endurance athlete status (df = 4, χ2 = 4.1, P = 0.39). In addition, genotype at 22982 was not associated with elite endurance athlete status (df = 4, χ2 = 5.7, P = 0.23). Nor was the A allele at 22982, which is associated with lower ACE activity, more prevalent in N (0.52) or I (0.41) relative to C (0.53). We conclude that ACE I/D and A22982G polymorphisms are not strongly associated with elite endurance athlete status amongst Kenyans. © 2005 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Scott, Robert A.
Unknown Affiliation
Moran, Colin
Unknown Affiliation
Wilson, Richard H.
Unknown Affiliation
Onywera, Vincent Ochieng
Unknown Affiliation
Boit, M. K.
Unknown Affiliation
Goodwin, William H.
Unknown Affiliation
Gohlke, Peter
Unknown Affiliation
Payne, John
Unknown Affiliation
Montgomery, Hugh E.
Unknown Affiliation
Pitsiladis, Yannis Paul
Unknown Affiliation
Statistics
Citations: 102
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.cbpb.2005.05.001
ISSN:
10956433
e-ISSN:
15314332
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study