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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
16-KDa prolactin and bromocriptine in postpartum cardiomyopathy
Current Heart Failure Reports, Volume 9, No. 3, Year 2012
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Description
Peripartum cardiomyopathy (PPCM) is a potentially life-threatening heart disease emerging toward the end of pregnancy or in the first postpartal months in previously healthy women. Recent data suggest a central role of unbalanced peri-/postpartum oxidative stress that triggers the proteolytic cleavage of the nursing hormone prolactin (PRL) into a potent antiangiogenic, proapoptotic, and proinflammatory 16-kDa PRL fragment. This notion is supported by the observation that inhibition of PRL secretion by bromocriptine, a dopamine D2-receptor agonist, prevented the onset of disease in an animal model of PPCM and by first clinical experiences where bromocriptine seem to exert positive effects with respect to prevention or treatment of PPCM patients. Here, we highlight the current state of knowledge on diagnosis of PPCM, provide insights into the biology and pathophysiology of 16-kDa PRL and bromocriptine, and outline potential consequences for the clinical management and treatment options for PPCM patients. © Springer Science+Business Media, LLC 2012.
Authors & Co-Authors
Hilfiker-Kleiner, Denise
Germany, Hannover
Hannover Medical School
Struman, Ingrid
Germany, Hannover
Hannover Medical School
Hoch, Melanie
Germany, Hannover
Hannover Medical School
Podewski, Edith Katharina
Germany, Hannover
Hannover Medical School
South Africa, Cape Town
University of Cape Town
Sliwa, Karen S.
Belgium, Liege
Université de Liège
Statistics
Citations: 47
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1007/s11897-012-0095-7
e-ISSN:
15469549
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Participants Gender
Female