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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Divergence with gene flow in Anopheles funestus from the Sudan Savanna of Burkina Faso, West Africa
Genetics, Volume 173, No. 3, Year 2006
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Description
Anopheles funestus is a major vector of malaria across Africa. Understanding its complex and nonequilibrium population genetic structure is an important challenge that must be overcome before vector populations can be successfully perturbed for malaria control. Here we examine the role of chromosomal inversions in structuring genetic variation and facilitating divergence in Burkina Faso, West Africa, where two incipient species (chromosomal forms) of A. funestus, defined principally by rearrangements of chromosome 3R, have been hypothesized. Sampling across an ∼300-km east-west transect largely contained within the Sudan-Savanna ecoclimatic zone, we analyzed chromosomal inversions, 16 microsatellite loci distributed genomewide, and 834 bp of the mtDNA ND5 gene. Both molecular markers revealed high genetic diversity, nearly all of which was accounted for by within-population differences among individuals, owing to recent population expansion. Across the study area there was no correlation between genetic and geographic distance. Significant genetic differentiation found between chromosomal forms on the basis of microsatellites was not genomewide but could be explained by chromosome 3R alone on the basis of loci inside and near inversions. These data are not compatible with complete reproductive isolation but are consistent with differential introgression and sympatric divergence between the chromosomal forms, facilitated by chromosome 3R inversions. Copyright © 2006 by the Genetics Society of America.
Authors & Co-Authors
Michel, Andrew P.
United States, Notre Dame
University of Notre Dame
Grushko, Olga G.
United States, Notre Dame
University of Notre Dame
Guelbéogo, Wamdaogo Moussa
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Lobo, Neil Francis
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Sagnon, N'Falé F.
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Costantini, Carlo
France, Marseille
Ird Institut de Recherche Pour le Developpement
Besansky, Nora J.
United States, Notre Dame
University of Notre Dame
Statistics
Citations: 35
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1534/genetics.106.059667
ISSN:
00166731
e-ISSN:
00166731
Research Areas
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Burkina Faso
Sudan