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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda
Journal of Infectious Diseases, Volume 199, No. 7, Year 2009
Notification
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Description
Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878.) © 2009 by the Infectious Diseases Society of America.
Authors & Co-Authors
Tobian, Aaron A.R.
Unknown Affiliation
Charvat, Blake
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Ssempijja, Victor
Uganda, Kalisizo
Rakai Health Sciences Program
Kigozi, Godfrey G.
Uganda, Kampala
Makerere University
Serwadda, David Musoke
Uganda, Kampala
Makerere University
Makumbi, Fredrick Edward
Uganda, Kampala
Makerere University
Iga, Boaz
Uganda, Kalisizo
Rakai Health Sciences Program
Laeyendecker, Oliver B.
United States, Baltimore
Johns Hopkins School of Medicine
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Riedesel, Melissa A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Oliver, Amy E.
United States, Baltimore
Johns Hopkins School of Medicine
Chen, Michael Z.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Reynolds, Steven James
United States, Baltimore
Johns Hopkins School of Medicine
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Wawer, Maria J.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gray, Ronald H.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Quinn, Thomas Charles
United States, Baltimore
Johns Hopkins School of Medicine
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Statistics
Citations: 84
Authors: 15
Affiliations: 5
Identifiers
Doi:
10.1086/597074
ISSN:
00221899
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Substance Abuse
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Uganda
Participants Gender
Male