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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
In vitro antiplasmodial activity and toxicity assessment of some plants from Nigerian ethnomedicine
Pharmaceutical Biology, Volume 49, No. 1, Year 2011
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Description
Context: The emergence and spread of Plasmodium falciparum-resistant parasites to nearly all available antimalarial drugs pose a threat to malaria control and necessitates the need to continue the search for new effective and affordable drugs. Ethnomedicine has been shown to be a potential source of antimalarial compounds or source of template for the synthesis of novel antimalarial molecules. Objective: The antiplasmodial activity and toxicity assessment of 30 plant extracts from eight medicinal plants identified in Nigerian ethnomedicine for the treatment of febrile illnesses were evaluated. Materials and methods: In vitro antimalarial activity was evaluated using Plasmodium falciparum NF54 (sensitive to all antimalarial drugs) and K1 (chloroquine/pyrimethamine resistant) strains in the [3H]- hypoxanthine incorporation assay. Toxicity was determined against mammalian L6 cells using Alamar blue assay. Results: The ethyl acetate extract of leaves of Ocimum gratissimum Linn. (Labiatae) and hexane extract of stem bark of Trema orientalis (L.) Blume (Ulmaceae) showed the highest antiplasmodial activity (IC50 1.8-1.93 g/mL) against P. falciparum K1 strain but elicited low cytotoxicity (selective index >10). However, hexane, ethyl acetate or methanol extracts of leaves of Terminalia catappa Linn. (Combretaceae), Jatropha curcas Linn. (Euphorbiaceae), Vitex doniana Sweet. (Verbenaceae) and stem bark of Vitex doniana displayed antiplasmodial activity (IC50 2.3-16.9 g/mL) with good selectivity (21-120) for malaria parasites. Discussion and conclusion: The antiplasmodial activity of Terminalia catappa and Vitex doniana against P. falciparum K1 is being reported for the first time in Nigerian ethnomedicine and these plants could be potential source of antimalarial agents. © 2011 Informa Healthcare USA, Inc.
Authors & Co-Authors
Abiodun, Oyindamola Olajumoke
Nigeria, Ogbomoso
Ladoke Akintola University of Technology
Nigeria, Ibadan
University of Ibadan
Gbotosho, Grace Olusola
Nigeria, Ibadan
University of Ibadan
Ajaiyeoba, Edith Oriabure
Nigeria, Ibadan
University of Ibadan
Happi, Christian Tientcha
Nigeria, Ibadan
University of Ibadan
Falade, Mofolusho O.
Nigeria, Ibadan
University of Ibadan
Nigeria, Ede
Redeemer‘s University
Wittlin, Sergio
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Sowunmi, Akintunde
Nigeria, Ibadan
University of Ibadan
Brun, Reto
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Oduola, Ayoade M.J.
Switzerland, Geneva
Organisation Mondiale de la Santé
Statistics
Citations: 67
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.3109/13880209.2010.490224
ISSN:
13880209
e-ISSN:
17445116
Research Areas
Health System And Policy
Infectious Diseases