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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
SRY interacts with ribosomal proteins S7 and L13a in nuclear speckles
Cell Biology International, Volume 35, No. 5, Year 2011
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Description
The SRY (sex-determining region on the Y chromosome) is essential for male development; however, the molecular mechanism by which the SRY induces testis development is still unclear. To elucidate the mechanism of testis development, we identified SRY-interacting proteins using a yeast two-hybrid system. We found two ribosomal proteins, RPS7 (ribosomal protein S7) and RPL13a (ribosomal protein L13a) that interact with the HMG (high-mobility group) box domain of SRY. Furthermore, we confirmed the intracellular distributions of RPS7, RPL13a and SRY and found that the three proteins were co-expressed in COS1 cells. SRY, RPS7 and RPL13a were co-localized in nuclear speckles. These findings suggest that SRY plays an important role in activities associated with nuclear speckles via an unknown mechanism. © The Author(s) Journal compilation © 2011 Portland Press Limited.
Authors & Co-Authors
Ewis, Ashraf Abd Elazeem
Japan, Tokushima
Graduate School of Medical Sciences
Nakahori, Yutaka
Japan, Tokushima
Graduate School of Medical Sciences
Statistics
Citations: 7
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1042/CBI20090201
ISSN:
10958355
Research Areas
Cancer
Participants Gender
Male