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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnosing diffuse lung disease in children in a middle-income country: The role of open lung biopsy
International Journal of Tuberculosis and Lung Disease, Volume 21, No. 8, Year 2017
Notification
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Description
SETTING: A tertiary care hospital situated in a middleincome country with a high burden of tuberculosis (TB) and human immunodeficiency virus (HIV) infection. OBJECTIVE : To determine the diagnostic yield of open lung biopsy (OLB) in children with diffuse lung disease (DLD), comparing findings in HIV-infected and non- HIV-infected children. DESIGN: This 9-year retrospective study included 51 children with DLD (oxygen-dependent or on artificial ventilation), who required an OLB where the diagnosis remained uncertain after extensive investigations. RESULT S : The median age was 7 months, median body weight was 6.6 kg (61% were severely malnourished) and 30% were HIV-infected (62% on antiretroviral treatment). The diagnostic yield of the OLB was 86% (n 44) and was significantly higher in HIV-infected (77%) than in non-HIV-infected (48%) children (P 0.01). Pneumonia was the most common diagnosis (n 25, 57%), with common agents being cytomegalovirus (CMV), viruses other than CMV, Pneumocystis jiroveci pneumonia and previously undiagnosed TB (10%). Mycobacterium tuberculosis as a cause of DLD was not suspected before the OLB, as all investigations for TB were negative. Non-infectious causes of DLD were established in 10% of cases. CONCLUS ION: The OLB is a useful diagnostic tool to diagnose idiopathic DLD, including TB, in young children. © 2017 The Union.
Authors & Co-Authors
Gie, A. G.
South Africa, Cape Town
Faculty of Medicine and Health Sciences
Morrison, Julie Lyn
South Africa, Cape Town
Faculty of Medicine and Health Sciences
Gie, Robert Peter
South Africa, Cape Town
Faculty of Medicine and Health Sciences
Schubert, Pawel Tomasz
South Africa, Stellenbosch
Stellenbosch University
Jansen, J.
South Africa, Stellenbosch
Stellenbosch University
Kling, Sharon
South Africa, Cape Town
Faculty of Medicine and Health Sciences
Goussard, Pierre
South Africa, Cape Town
Faculty of Medicine and Health Sciences
Statistics
Citations: 10
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.5588/ijtld.16.0853
ISSN:
10273719
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study