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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants
npj Vaccines, Volume 8, No. 1, Article 98, Year 2023
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Description
As part of a multicenter study evaluating homologous and heterologous COVID-19 booster vaccines, we assessed the magnitude, breadth, and short-term durability of binding and pseudovirus-neutralizing antibody (PsVNA) responses following a single booster dose of NVX-CoV2373 in adults primed with either Ad26.COV2.S, mRNA-1273, or BNT162b2 vaccines. NVX-CoV2373 as a heterologous booster was immunogenic and associated with no safety concerns through Day 91. Fold-rises in PsVNA titers from baseline (Day 1) to Day 29 were highest for prototypic D614G variant and lowest for more recent Omicron sub-lineages BQ.1.1 and XBB.1. Peak humoral responses against all SARS-CoV-2 variants were lower in those primed with Ad26.COV2.S than with mRNA vaccines. Prior SARS CoV-2 infection was associated with substantially higher baseline PsVNA titers, which remained elevated relative to previously uninfected participants through Day 91. These data support the use of heterologous protein-based booster vaccines as an acceptable alternative to mRNA or adenoviral-based COVID-19 booster vaccines. This trial was conducted under ClinicalTrials.gov: NCT04889209. © 2023, The Author(s).
Authors & Co-Authors
Lyke, Kirsten E.
United States, Baltimore
University of Maryland School of Medicine
Atmar, Robert L.
United States, Houston
Baylor College of Medicine
Posavad, Christine M.
United States, Seattle
Fred Hutchinson Cancer Center
Branche, Angela R.
United States, Rochester
University of Rochester
Johnston, Christine M.
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
El-Sahly, Hana Mohammed
United States, Houston
Baylor College of Medicine
Edupuganti, Srilatha
United States, Atlanta
Emory University School of Medicine
United States, Atlanta
Emory University
Mulligan, Mark J.
United States, New York
Nyu Langone Health
Jackson, Lisa A.
United States, Oakland
Kaiser Permanente
Rupp, Richard E.
United States, Galveston
The University of Texas Medical Branch at Galveston
Coler, Rhea N.
United States, Seattle
University of Washington School of Medicine
Babu, Tara M.
United States, Seattle
University of Washington
Martin, Judith Marie
United States, Pittsburgh
University of Pittsburgh School of Medicine
Frenck, Robert W.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Kotloff, Karen L.
United States, Baltimore
University of Maryland School of Medicine
Rouphael, Nadine G.
United States, Atlanta
Emory University School of Medicine
United States, Atlanta
Emory University
Szydlo, Daniel W.
United States, Seattle
Fred Hutchinson Cancer Center
Eaton, Amanda
United States, Durham
Duke University Medical Center
Brown, Elizabeth R.
United States, Seattle
Fred Hutchinson Cancer Center
McElrath, Margaret Juliana
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Neuzil, Kathleen Maletic
United States, Baltimore
University of Maryland School of Medicine
Stephens, David
United States, Atlanta
Emory University School of Medicine
Lin, Bob C.
United States, Bethesda
National Institutes of Health Nih
Serebryannyy, Leonid A.
United States, Bethesda
National Institutes of Health Nih
Beigel, John H.
United States, Bethesda
National Institutes of Health Nih
Montefiori, David C.
United States, Durham
Duke University Medical Center
Anderson, Evan J.
United States, Atlanta
Emory University School of Medicine
Cohen, Kristen W.
United States, Seattle
Fred Hutchinson Cancer Center
de Rosa, Stephen C.
United States, Seattle
Fred Hutchinson Cancer Center
Falsey, Ann Regina
United States, Rochester
University of Rochester
Graciaa, Daniel S.
United States, Atlanta
Emory University
Suthar, Mehul S.
United States, Atlanta
Emory University
Wald, Anna
United States, Seattle
University of Washington
Statistics
Citations: 2
Authors: 33
Affiliations: 17
Identifiers
Doi:
10.1038/s41541-023-00693-z
ISSN:
20590105
Research Areas
Covid