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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Lactobacillus plantarum HAC01 regulates gut microbiota and adipose tissue accumulation in a diet-induced obesity murine model
Applied Microbiology and Biotechnology, Volume 101, No. 4, Year 2017
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Description
The functional features of Lactobacillus plantarum HAC01 (HAC01), isolated from fermented Korean kimchi, were studied with regard to the fat mass, immunometabolic biomarkers and dysbiosis in a diet-induced obesity (DIO) murine model. L. rhamnosus GG (LGG) served as reference strain and a PBS-treated group as control. The administration of L. plantarum HAC01 resulted in reduction of the mesenteric adipose depot, the conjunctive tissue closely associated with the gastrointestinal tract, where lipid oxidative gene expression was upregulated compared to the control group. Metagenome analysis of intestinal microbiota showed that both strains HAC01 and LGG influenced specific bacterial families such as the Lachnospiraceae and Ruminococcaceae rather than the phyla Firmicutes and Bacteroidetes as a whole. The relative abundance of the Lachnospiraceae (phylum Firmicutes) was significantly higher in both LAB-treated groups than in the control. Comparing the impact of the two Lactobacillus strains on microbial composition in the gut also suggests strain-specific effects. The study emphasises the need for deeper studies into functional specificity of a probiotic organism at the strain level. Alleviation of obesity-associated dysbiosis by modulation of the gut microbiota appears to be associated with “indicator” bacterial taxa such as the family Lachnospiraceae. This may provide further insight into mechanisms basic to the mode of probiotic action against obesity and associated dysbiosis. © 2016, Springer-Verlag Berlin Heidelberg.
Authors & Co-Authors
Park, Soyoung
South Korea, Pohang
Handong Global University
Ji, Yosep
South Korea, Pohang
Handong Global University
Park, Hyunjoon
South Korea, Pohang
Handong Global University
Kang, Jihee
South Korea, Daejeon
Atogen Co., Ltd.
Choi, Sanghaeng
South Korea, Daejeon
Atogen Co., Ltd.
Shin, Heuynkil
South Korea, Pohang
Handong Global University
Kim, K. T.
South Korea, Pohang
Pohang University of Science and Technology
Holzapfel, Wilhelm Heinrich
South Korea, Pohang
Handong Global University
Statistics
Citations: 103
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1007/s00253-016-7953-2
ISSN:
01757598
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Randomised Control Trial