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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Distinct, specific IL-17- and IL-22-producing CD4
+
T cell subsets contribute to the human anti-mycobacterial immune response
Journal of Immunology, Volume 180, No. 3, Year 2008
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Description
We investigated whether the proinflammatory T cell cytokines IL-17 and IL-22 are induced by human mycobacterial infection. Remarkably, >20% of specific cytokine-producing CD4+ T cells in peripheral blood of healthy, mycobacteria-exposed adults expressed IL-17 or IL-22. Specific IL-17- and IL-22-producing CD4+ T cells were distinct from each other and from Th1 cytokine-producing cells. These cells had phenotypic characteristics of long-lived central memory cells. In patients with tuberculosis disease, peripheral blood frequencies of these cells were reduced, whereas bronchoalveolar lavage fluid contained higher levels of IL-22 protein compared with healthy controls. IL-17 was not detected in this fluid, which may be due to suppression by Th1 cytokines, as PBMC IL-17 production was inhibited by IFN-γ in vitro. However, Th1 cytokines had no effect on IL-22 production in vitro. Our results imply that the magnitude and complexity of the anti-mycobacterial immune response have historically been underestimated. IL-17- and IL-22-producing CD4+ T cells may play important roles in the human immune response to mycobacteria. Copyright © 2008 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Scriba, Thomas J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Kalsdorf, Barbara
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Abrahams, Deborah Ann
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Isaacs, Fatima
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hofmeister, Jessica
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Black, Gillian Frances
South Africa, Stellenbosch
Stellenbosch University
Hassan, Hisham Y.
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Wilkinson, Robert J.
South Africa, Cape Town
University of Cape Town
United Kingdom, London
Wellcome Trust
United Kingdom, London
Mrc National Institute for Medical Research
Walzl, Gerhard
South Africa, Stellenbosch
Stellenbosch University
Gelderbloem, Sebastian J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Mahomed, Hassan
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hussey, Greg Dudley
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Statistics
Citations: 418
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.4049/jimmunol.180.3.1962
ISSN:
00221767
e-ISSN:
15506606