Publication Details

AFRICAN RESEARCH NEXUS

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biochemistry, genetics and molecular biology

The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development

Developmental Cell, Volume 50, No. 5, Year 2019

Ritter et al. characterize an essential lncRNA locus, Handsdown, which regulates development by controlling cardiac gene programs during early vertebrate embryo formation. The Handsdown locus physically interacts with the Hand2 gene during cardiac differentiation and genetic ablation of Handsdown leads to elevated Hand2 levels.

Statistics
Citations: 59
Authors: 10
Affiliations: 5
Identifiers
Doi: 10.1016/j.devcel.2019.07.013
ISSN: 15345807
e-ISSN: 18781551
Research Areas
Genetics And Genomics
Noncommunicable Diseases

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