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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated Plasmodium falciparum malaria: A pooled analysis
American Journal of Tropical Medicine and Hygiene, Volume 85, No. 5, Year 2011
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Description
Randomized trials have confirmed the efficacy and safety of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria. Data from seven studies supported by Novartis (1996-2007), including 647 adults (> 16 years of age, 83.3% completed the study) and 1,332 children (≤ 16 years of age, 89.3% completed the study) with microscopically confirmed uncomplicated P. falciparum malaria and treated with the recommended regimen of AL, were pooled. The 28-day polymerase chain reaction-corrected parasitologic cure rate (primary efficacy endpoint) was 97.1% (495 of 510) in adults and 97.3% (792 of 814) in children (evaluable population). Gametocytemia prevalence after day was 4.2% (23 of 554) in adults and 0.9% (8 of 846) in children. No noteworthy safety signals were observed. Serious adverse events occurred in 1.4% of the adults and 1.3% of the children. This study is the largest data set to date assessing AL therapy for treatment of acute uncomplicated P. falciparum malaria. Artemether-lumefantrine showed high cure rates and rapid resolution of parasitemia, fever, and gametocytemia in adults and children, and showed an excellent safety and tolerability profile. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Makanga, Michael M.
Unknown Affiliation
Bassat, Quique
Unknown Affiliation
Falade, Catherine Olufunke
Unknown Affiliation
Premji, Zulfiqarali G.
Unknown Affiliation
Krudsood, Srivicha
Unknown Affiliation
Hunt, Philip
Unknown Affiliation
Walter, Verena
Unknown Affiliation
Beck, Hans Peter
Unknown Affiliation
Marrast, Anne Claire
Unknown Affiliation
Cousin, Marc
Unknown Affiliation
Rosenthal, Philip Jon
Unknown Affiliation
Statistics
Citations: 55
Authors: 11
Affiliations: 11
Identifiers
Doi:
10.4269/ajtmh.2011.11-0069
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study