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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High Mycoplasma genitalium organism burden is associated with shedding of HIV-1 DNA from the cervix
Journal of Infectious Diseases, Volume 197, No. 5, Year 2008
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Description
We assessed the relationship between infection with Mycoplasma genitalium, an emerging sexually transmitted pathogen, and cervical shedding of human immunodeficiency virus (HIV)-1 DNA among 303 HIV-1-positive Kenyan women. HIV-1 shedding was detected by qualitative polymerase chain reaction (PCR) in 154 women (51%); M. genitalium was detected by qualitative PCR in 52 (17%), and organism burden was determined by quantitative PCR. Women with high M. genitalium organism burdens (more than the median of 3195 genomes/mL) were 3-fold more likely to shed HIV-1 DNA than were M. genitalium-negative women (adjusted OR, 2.9 [95% confidence interval, 1.1-7.6]), yet this did not appear to be mediated by traditional measures of cervical inflammation (elevated polymorphonuclear leukocyte count). © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Manhart, Lisa E.
United States, Seattle
University of Washington
United States, Seattle
Uw Center for Aids and Std
Mostad, Sara B.
United States, Seattle
University of Washington
Baeten, Jared M.
United States, Seattle
University of Washington
Astete, Sabina G.
United States, Seattle
University of Washington
Mandaliya, Kishor N.
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Totten, Patricia A.
United States, Seattle
University of Washington
Statistics
Citations: 91
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1086/526501
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Study Approach
Qualitative
Quantitative
Participants Gender
Female