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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV type 2 protease, reverse transcriptase, and envelope viral variation in the PBMC and genital tract of ARV-naive women in Senegal
AIDS Research and Human Retroviruses, Volume 24, No. 6, Year 2008
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Description
Unique viral variants and resistance mutations may occur in the genital tract of HIV-2 ARV-naive infected women. We sequenced and phylogenetically analyzed protease (PR), reverse transcriptase (RT), and envelope (ENV) from PBMC and genital tract samples from four ARV-naive women in Senegal. HIV-2 protease polymorphisms that predict HIV-1 protease inhibitor (PI) resistance were common. Two subjects had protease mutations (T77I and I64V) in genital tract samples that were not found in PBMCs. One subject had the HIV-2 reverse transcriptase M184I mutation in CVL DNA (but not PBMCs) that is known to confer 3TC/FTC resistance in HIV-2. In another subject, the reverse transcriptase A62V mutation was also found in CVL-RNA but not PBMCs. We found no significant difference in ENV variants between PBMCs and the genital tract. HIV-2 RT and PR mutations in the genital tract of ARV-naive females may have implications for transmitted HIV-2 resistance and ARV therapy. © 2008 Mary Ann Liebert, Inc.
Authors & Co-Authors
Gottlieb., Geoffrey S.
United States, Seattle
University of Washington School of Medicine
United States, Seattle
University of Washington
Hawes, Stephen Edward
United States, Seattle
University of Washington School of Public Health and Community Medicine
Wong, Kim G.
United States, Seattle
University of Washington School of Medicine
Raugi, Dana Noelle
United States, Seattle
University of Washington School of Medicine
Agne, Habibatou D.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Critchlow, Cathy W.
United States, Seattle
University of Washington School of Public Health and Community Medicine
Kiviat, Nancy B.
United States, Seattle
University of Washington School of Medicine
Sow, Papa Salif
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Statistics
Citations: 12
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1089/aid.2008.0015
ISSN:
08892229
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Locations
Senegal
Participants Gender
Female