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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
p53 mutation in hepatocellular carcinoma after aflatoxin exposure
The Lancet, Volume 338, No. 8779, Year 1991
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Description
Mutations of the p53 gene are found in hepatocellular carcinoma (HCC), the most common form of primary liver cancer. Specific mutations might reflect exposure to specific carcinogens and we have screened HCC samples from patients in 14 different countries to determine the frequency of a hotspot mutation at codon 249 of the tumour suppressor p53 gene. We detected mutations in 17% of tumours (12/72) from four countries in south Africa and the southeast coast of Asia. There was no codon 249 mutation in 95 specimens of HCC from other geographical locations including North America, Europe, Middle East, and Japan. Worldwide, the presence of the codon 249 mutation in HCCs correlated with high risk of exposure to aflatoxins and the hepatitis B virus (HBV). Further studies were completed in two groups of HBV-infected patients at different risks of exposure to aflatoxins. 53% of patients (8/15) from Mozambique at high risk of aflatoxin exposure had a tumour with a codon 249 mutation, in contrast with 8% of patients from Transkei (1/12) who were at low risk. HCC is an endemic disease in Mozambique and accounts for up to two thirds of all tumours in men. A codon 249 mutation of the p53 gene identifies an endemic form of HCC strongly associated with dietary aflatoxin intake. © 1991.
Authors & Co-Authors
Bressac, Brigitte
United States, Boston
Massachusetts General Hospital Cancer Center
Puisieux, Alain
United States, Boston
Massachusetts General Hospital Cancer Center
Kew, Michael C.
South Africa, Johannesburg
University of the Witwatersrand
Volkmann, Martin
Germany, Heidelberg
German Cancer Research Center
Bozcall, Sema
United States, Boston
Massachusetts General Hospital
Bella Mura, Jessika
United States, Boston
Massachusetts General Hospital
de la Monte, Suzanne
United States, Boston
Massachusetts General Hospital
Carlson, Rolf
United States, Boston
Massachusetts General Hospital
Blum, Hubert
United States, Boston
Massachusetts General Hospital
Wands, Jack
United States, Boston
Massachusetts General Hospital
Takahashi, Hiroshi
United States, Boston
Massachusetts General Hospital
von Weizsäcker, Fritz
United States, Boston
Massachusetts General Hospital
Galun, Elthan
United States, Boston
Massachusetts General Hospital
Kar, Siddhartha
United States, Pittsburgh
University of Pittsburgh School of Medicine
Carr, Brian I.
United States, Pittsburgh
University of Pittsburgh School of Medicine
Schroder, Claus H.
Germany, Heidelberg
German Cancer Research Center
Erken, Eren
Turkey, Adana
Çukurova Üniversitesi
Varinli, Seyhan
Turkey, Adana
Çukurova Üniversitesi
Rustgi, Vinod K.
United States, Falls Church
Fairfax Hospital
Prat, Jaime
Spain
Hospital de la Santa Creu I San Pau
Toda, Gotaro
Japan, Tokyo
The Jikei University School of Medicine
Koch, Herbert K.
Germany, Tubingen
Institut Für Pathologie
Huan Liang, Xiao
China, Shanghai
Shanghai Medical College Fudan University
Tang, Zhao you
China, Shanghai
Shanghai Medical College Fudan University
Shouval, Daniel
Israel, Jerusalem
Hadassah University Medical Centre
Lee, Hyo Suk
South Korea, Seoul
Seoul National University College of Medicine
Vyas, Girish N.
United States, Albany
University of California
Sarosi, Ildiko
United States, Albany
University of California
Öztürk, Mehmet Evren
Unknown Affiliation
Statistics
Citations: 483
Authors: 29
Affiliations: 14
Identifiers
Doi:
10.1016/0140-6736(91)92236-U
ISSN:
01406736
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Locations
Mozambique
South Africa
Participants Gender
Male