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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Baseline characteristics of the 4011 patients recruited into the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trial
International Journal of Stroke, Volume 9, No. 6, Year 2014
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Description
Background: High blood pressure is common in acute stroke and associated with a worse functional outcome. Many patients who present with acute stroke are taking prescribed antihypertensive therapy before their stroke. Aims: ENOS tested whether lowering blood pressure and continuing pre-stroke antihypertensive therapy are each safe and effective. Methods: This study is an international multi-centre prospective randomized single-blind blinded-endpoint parallel-group partial-factorial controlled trial of transdermal glyceryl trinitrate (a nitric oxide donor, given for seven-days) vs. no glyceryl trinitrate, and of continuing vs. stopping (temporarily for seven-days) pre-stroke antihypertensive drugs if relevant, in patients with acute ischaemic stroke or intracerebral haemorrhage and high systolic blood pressure (140-220mmHg). Results: Recruitment ran from July 2001 to October 2013. Four thousand eleven patients [2097 (52·3%) in the continue/stop arm] were recruited from 173 sites across 23 countries in 5 continents (Asia 14%, Continental Europe 16%, UK 64%). Baseline characteristics include: mean age 70 (standard deviation 12) years; male 57%; mean time from stroke to recruitment 26 (13) h; mean severity (Scandinavian Stroke Scale) 34 (13) of 58; mean blood pressure 167 (19)/90 (13)mmHg; ischaemic stroke 83%; and intracerebral haemorrhage 16%. The main trial results will be presented in May 2014. The results will also be presented in updated Cochrane systematic reviews and included in individual patient data meta-analyses of all relevant randomized controlled trials. Conclusion: ENOS is a large completed international trial of blood pressure management in acute stroke and includes patients representative of many stroke services worldwide. International Journal of Stroke © 2014 World Stroke Organization.
Authors & Co-Authors
Bath, Philip M.
Unknown Affiliation
Adami, Alessandro
Unknown Affiliation
Dániel, Bereczki
Unknown Affiliation
Berge, Eivind
Unknown Affiliation
Beridze, Maia Z.
Unknown Affiliation
Cala, Lesley Ann
Unknown Affiliation
Casado, Ana
Unknown Affiliation
Caso, Valeria
Unknown Affiliation
Chang, Hui Meng
Unknown Affiliation
Christensen, Hanne Krarup
Unknown Affiliation
Collins, Rónán D.
Unknown Affiliation
Członkowska, Anna
Unknown Affiliation
Dineen, Robert A.
Unknown Affiliation
Etribi, Anwar El
Unknown Affiliation
Ghani, Abdul Rahman Izaini
Unknown Affiliation
Gommans, John
Unknown Affiliation
Koumellis, Panos
Unknown Affiliation
Laska, Ann Charlotte
Unknown Affiliation
Lees, Kennedy R.
Unknown Affiliation
Navarro, Jose
Unknown Affiliation
Ntaios, George C.
Unknown Affiliation
Öztürk, Şerefnur
Unknown Affiliation
Phillips, Stephen
Unknown Affiliation
Pocock, Stuart J.
Unknown Affiliation
Prasad, Kameshwar Nagendra
Unknown Affiliation
Scutt, Polly
Unknown Affiliation
de Silva, Hithanadura Asita
Unknown Affiliation
Szatmári, Szabolcs
Unknown Affiliation
Exuperio Díez-Tejedor,
Unknown Affiliation
Utton, Sally
Unknown Affiliation
Wang, Yongjun
Unknown Affiliation
Joanna, M. Wardlaw
Unknown Affiliation
Whynes, David K.
Unknown Affiliation
Wong, Lawrence Ka Sing
Unknown Affiliation
Woodhouse, Lisa J.
Unknown Affiliation
Sprigg, Nikola
Unknown Affiliation
Statistics
Citations: 36
Authors: 36
Affiliations: 30
Identifiers
Doi:
10.1111/ijs.12308
e-ISSN:
17474949
Research Areas
Disability
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study
Participants Gender
Male