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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Increased incidence of mouse mammary tumor virus‐related antigen in tunisian patients with breast cancer
International Journal of Cancer, Volume 33, No. 3, Year 1984
Notification
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Description
Biopsies obtained from 74 Tunisian women with breast cancer (33 cases), benign breast disease (17 cases), and cervical cancer (24 cases) were assayed for the presence of an antigen cross‐reacting with gp52 of the mouse mammary tumor virus (MMTV) in order to determine the frequency and possible prognostic significance of this antigen in a form of rapidly progressing breast cancer designated poussée évolutive or PEV. Antigen was detected in 23/33 breast carcinomas (70%) but in none of the 41 control specimens. An evaluation of reactivity according to tumor aggressiveness and survival could be performed in retrospect on 29 of the breast cancer patients with a follow‐up of up to 11 years. The frequency of gp52‐related antigen was similar in the patients with the most aggressive form of PEV with inflammatory signs (8/12 or 67% positive) and those breast cancer patients without PEV (12/17 or 71% positive). Within each of the two groups, PEV+and PEV O, no correlation was observed between the presence or absence of antigen and the disease‐free interval or survival. We conclude that the identification of gp52‐related antigens in the breast cancer biopsies from North African women has implications different from these observed in other populations. While thus far not indicative of disease aggressiveness and prognosis, the higher frequency of detectable antigen in comparison to biopsies obtained from patients born in the United States and Europe may have relevance to the etiology and pathogenesis of this disease. Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Levine, Paul H.
United States, Rockville
National Cancer Institute Nci
Mesa‐Tejada, R.
United States, New York
Institute of Cancer Research
Keydar, I.
United States, New York
Institute of Cancer Research
Tabbane, Françoise
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Spiefelman, S.
United States, New York
Institute of Cancer Research
Mourali, Nejib
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Statistics
Citations: 44
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1002/ijc.2910330305
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer
Study Design
Cohort Study
Participants Gender
Female