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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Association of the MTHFR A1298C variant with unexplained severe male infertility
PLoS ONE, Volume 7, No. 3, Article e34111, Year 2012
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Description
The methylenetetrahydrofolate reductase (MTHFR) gene is one of the main regulatory enzymes involved in folate metabolism, DNA synthesis and remethylation reactions. The influence of MTHFR variants on male infertility is not completely understood. The objective of this study was to analyze the distribution of the MTHFR C677T and A1298C variants using PCR-Restriction Fragment Length Polymorphism (RFLP) in a case group consisting of 344 men with unexplained reduced sperm counts compared to 617 ancestry-matched fertile or normozoospermic controls. The Chi square test was used to analyze the genotype distributions of MTHFR polymorphisms. Our data indicated a lack of association of the C677T variant with infertility. However, the homozygous (C/C) A1298C polymorphism of the MTHFR gene was present at a statistically high significance in severe oligozoospermia group compared with controls (OR = 3.372, 95% confidence interval CI = 1.27-8.238; p = 0.01431). The genotype distribution of the A1298C variants showed significant deviation from the expected Hardy-Weinberg equilibrium, suggesting that purifying selection may be acting on the 1298CC genotype. Further studies are necessary to determine the influence of the environment, especially the consumption of diet folate on sperm counts of men with different MTHFR variants. © 2012 Eloualid et al.
Authors & Co-Authors
Eloualid, Abdelmajid
Morocco, Casablanca
Institut Pasteur du Maroc
Morocco, Casablanca
Faculté Des Sciences Ben M’sick
Abidi, Omar
Morocco, Casablanca
Institut Pasteur du Maroc
Charif, Majida
Morocco, Casablanca
Institut Pasteur du Maroc
El Houate, B.
Morocco, Casablanca
Institut Pasteur du Maroc
Benrahma, Houda
Morocco, Casablanca
Institut Pasteur du Maroc
Louanjli, Noureddine
Morocco, Casablanca
In Vitro Fecondation Center
Chadli, Elbakkay Bekkay
Morocco, Casablanca
Institut Pasteur du Maroc
Ajjemami, Maria
Morocco, Casablanca
Institut Pasteur du Maroc
Barakat, Abdelhamid
Morocco, Casablanca
Institut Pasteur du Maroc
Bashamboo, Anu
France, Paris
Institut Pasteur, Paris
McElreavey, Ken D.
France, Paris
Institut Pasteur, Paris
Rhaissi, Houria
Morocco, Casablanca
Faculté Des Sciences Ben M’sick
Rouba, Hassan
Morocco, Casablanca
Institut Pasteur du Maroc
Statistics
Citations: 39
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0034111
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Sexual And Reproductive Health
Participants Gender
Male