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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome
Cell Host and Microbe, Volume 19, No. 3, Year 2016
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Description
Human immunodeficiency virus (HIV) infection is associated with increased intestinal translocation of microbial products and enteropathy as well as alterations in gut bacterial communities. However, whether the enteric virome contributes to this infection and resulting immunodeficiency remains unknown. We characterized the enteric virome and bacterial microbiome in a cohort of Ugandan patients, including HIV-uninfected or HIV-infected subjects and those either treated with anti-retroviral therapy (ART) or untreated. Low peripheral CD4 T cell counts were associated with an expansion of enteric adenovirus sequences and this increase was independent of ART treatment. Additionally, the enteric bacterial microbiome of patients with lower CD4 T counts exhibited reduced phylogenetic diversity and richness with specific bacteria showing differential abundance, including increases in Enterobacteriaceae, which have been associated with inflammation. Thus, immunodeficiency in progressive HIV infection is associated with alterations in the enteric virome and bacterial microbiome, which may contribute to AIDS-associated enteropathy and disease progression. © 2016 Elsevier Inc.
Authors & Co-Authors
Monaco, Cynthia L.
United States, St. Louis
Washington University School of Medicine in St. Louis
Zhao, Guoyan
United States, St. Louis
Washington University School of Medicine in St. Louis
Handley, Scott A.
United States, St. Louis
Washington University School of Medicine in St. Louis
Ghebremichael, Musie S.
United States, Cambridge
Massachusetts Institute of Technology
Lim, Efrem S.
United States, St. Louis
Washington University School of Medicine in St. Louis
Lankowski, Alexander J.
United States, Boston
Harvard Medical School
Baldridge, Megan T.
United States, St. Louis
Washington University School of Medicine in St. Louis
Wilen, Craig B.
United States, St. Louis
Washington University School of Medicine in St. Louis
Wang, David
United States, St. Louis
Washington University School of Medicine in St. Louis
Boum, Yap I.
Switzerland, Geneva
Medecins Sans Frontieres
Martin, Jeffrey N.
United States, San Francisco
University of California, San Francisco
Hunt, Peter W.
United States, San Francisco
University of California, San Francisco
Bangsberg, David R.
United States, Boston
Harvard Medical School
United States, Boston
Harvard T.h. Chan School of Public Health
Siedner, Mark Jacob
United States, Boston
Harvard Medical School
Kwon, Douglas
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
Virgin, Herbert W.
United States, St. Louis
Washington University School of Medicine in St. Louis
Statistics
Citations: 265
Authors: 16
Affiliations: 7
Identifiers
Doi:
10.1016/j.chom.2016.02.011
ISSN:
19313128
Research Areas
Infectious Diseases
Study Design
Cohort Study