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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Hematologic parameters in pediatric uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa
American Journal of Tropical Medicine and Hygiene, Volume 85, No. 4, Year 2011
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Description
Hematologic changes in acute and convalescent uncomplicated Plasmodium falciparum malaria have not been well studied, particularly in young children in Africa. Hematologic data were obtained for 3,044 children less than five years of age in seven randomized controlled trials at 14 sites. Using paired analysis between day 28 and baseline in patients without parasitologic failure as a proxy for malaria-induced effects, we found a statistically significant but clinically modest increase in leukocyte counts (5%) resulting from a larger increase in neutrophils (43%) than the decrease in lymphocytes counts (-16%); levels of hemoglobin and platelets decreased (-13% and -49%, respectively). Multivariate random effects analysis showed trends during follow-up (increased levels of hemoglobin, platelets and lymphocytes, and decreased levels of leukocytes and neutrophils) and identified explanatory variables. The risk of neutropenia increased with follow-up time independent of treatment outcome, and was lower with age, higher baseline parasitemia, and artemisinin combination treatment. These analyses provides information on hematologic variations caused by malaria. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Olliaro, Piero L.
Switzerland, Geneva
Organisation Mondiale de la Santé
United Kingdom, Oxford
Nuffield Department of Medicine
Sweden, Stockholm
Karolinska Institutet
Djimde, Abdoulaye A.
Mali, Bamako
University of Bamako
United Kingdom, Oxford
Nuffield Department of Medicine
Sweden, Stockholm
Karolinska Institutet
Dorsey, Grant M.
United States, San Francisco
Ucsf School of Medicine
United Kingdom, Oxford
Nuffield Department of Medicine
Sweden, Stockholm
Karolinska Institutet
Karema, Corine Kakizi
Rwanda, Kigali
National Malaria Control Program
United Kingdom, Oxford
Nuffield Department of Medicine
Sweden, Stockholm
Karolinska Institutet
Mårtensson, Andreas A.
Sweden, Stockholm
Karolinska Universitetssjukhuset
United Kingdom, Oxford
Nuffield Department of Medicine
Sweden, Stockholm
Karolinska Institutet
Ndiaye, Jean Louis Abdourahim
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
United Kingdom, Oxford
Nuffield Department of Medicine
Sweden, Stockholm
Karolinska Institutet
Sirima, Sodiomon Bienvenu
Burkina Faso, Ouagadougou
Ministere de la Sante Ouagadougou
United Kingdom, Oxford
Nuffield Department of Medicine
Sweden, Stockholm
Karolinska Institutet
Vaillant, Michel T.
Luxembourg
Centre de Recherche Publique-santé
United Kingdom, Oxford
Nuffield Department of Medicine
Sweden, Stockholm
Karolinska Institutet
Zwang, Julien
Switzerland, Geneve
Drugs for Neglected Diseases Initiative
United Kingdom, Oxford
Nuffield Department of Medicine
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 37
Authors: 9
Affiliations: 11
Identifiers
Doi:
10.4269/ajtmh.2011.11-0154
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study