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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression
Journal of Psychopharmacology, Volume 27, No. 10, Year 2013
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Description
Although antidepressants are widely used in the pharmacotherapy of major depressive disorder (MDD), their efficacy is still insufficient as approximately one-third of the patients do not fully recover even after several treatment trials. Inter-individual genetic differences are thought to contribute to the variability in antidepressant response; however, current findings from pharmacogenetic studies are uncertain or not clearly replicated. Here we report the first application of full exome sequencing for the analysis of pharmacogenomics on antidepressant treatment. After 12 weeks of treatment with the selective serotonin re-uptake inhibitor escitalopram, we selected five clear responders and five clear non-responders for exome sequencing. By comparing the allele counts of previously known single nucleotide polymorphisms and novel polymorphisms we selected 38 markers for further genotyping in two independent patient samples treated with escitalopram (n=116 and n=394). The A allele, carried by approximately 30% of the patients with MDD, of rs41271330 in the bone morphogenetic protein (BMP5) gene showed strong association with worse treatment response in both sample sets (p=0.001), indicating that this is an promising pharmacogenetic marker for prediction of antidepressant therapeutic outcome. © 2013 The Author(s).
Authors & Co-Authors
Tammiste, Anu
Estonia, Tartu
Tartu Ülikool
Estonia, Tartu
Tartu Ülikooli Genoomika Instituut
Jiang, Tao
China, Shenzhen
Bgi-shenzhen
Fischer, Krista
Estonia, Tartu
Tartu Ülikooli Genoomika Instituut
Mägi, Reedik
Estonia, Tartu
Tartu Ülikooli Genoomika Instituut
Krjutškov, Kaarel
Estonia, Tartu
Tartu Ülikooli Genoomika Instituut
Sweden, Stockholm
Karolinska Institutet
Estonia, Tartu
Competence Centre of Reproductive Medicine and Biology
Pettai, Kristi
Estonia, Tartu
Tartu Ülikooli Genoomika Instituut
Esko, Tönu
Estonia, Tartu
Tartu Ülikool
Estonia, Tartu
Tartu Ülikooli Genoomika Instituut
Li, Yingrui
China, Shenzhen
Bgi-shenzhen
Tansey, Katherine E.
United Kingdom, London
King's College London
Carroll, Liam S.
United Kingdom, London
King's College London
Uher, Rudolf
United Kingdom, London
King's College London
Canada, Halifax
Dalhousie University
McGuffin, Peter
United Kingdom, London
King's College London
Vosa, Urmo
Estonia, Tartu
Tartu Ülikool
Tšernikova, Natalia
Estonia, Tartu
Tartu Ülikool
Saria, Alois
Austria, Innsbruck
Medizinische Universitat Innsbruck
Ng, Pauline C.
Estonia, Tartu
Tartu Ülikooli Genoomika Instituut
Eller, Triin
Estonia, Tartu
Tartu Ülikool
Vasar, Veiko
Estonia, Tartu
Tartu Ülikool
Nutt, David John
United Kingdom, London
Imperial College London
Maron, Eduard
Estonia, Tartu
Tartu Ülikool
United Kingdom, London
Imperial College London
Wang, Jun
Estonia, Tartu
Tartu Ülikool
Denmark, Copenhagen
Novo Nordisk Foundation Center for Basic Metabolic Research
Saudi Arabia, Jeddah
King Abdulaziz University
Denmark, Aarhus
Aarhus Universitet
Metspalu, Andres H.
Estonia, Tartu
Tartu Ülikool
Estonia, Tartu
Tartu Ülikooli Genoomika Instituut
Statistics
Citations: 31
Authors: 22
Affiliations: 12
Identifiers
Doi:
10.1177/0269881113499829
ISSN:
02698811
e-ISSN:
14617285
Research Areas
Genetics And Genomics
Health System And Policy
Mental Health
Substance Abuse