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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Molecular genetic diversity of hepatitis B virus in kenya
Intervirology, Volume 51, No. 6, Year 2009
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Description
Eight genotypes of hepatitis B virus (A-H) and subgenotypes have been recognized worldwide. However, there is limited information on prevalent genotypes in many countries in Africa. This study was undertaken to determine the hepatitis B virus (HBV) genotypes in Kenya. Seropositive HBV blood samples from a blood donor setting were used in the study. HBV genotypes were determined in 52 nucleic acid-positive samples using specific primer in a nested PCR and sequencing employed in the HBV genotyping. This study shows presence of HBV variants with genotypes A (88%), E (8%) and D (4%). In conclusion, we found that HBV genotype A is the most predominant genotype in Kenya with both subgenotype A1 and A2 present. Genotype D and E are also present in our population. This demonstrates that there could be a high genetic diversity of HBV in Kenya. Copyright © 2009 S. Karger AG, Basel.
Authors & Co-Authors
Mwangi, Joseph M.
Kenya, Nairobi
Kenya Medical Research Institute
Ng'Ang'A, Zipporah W.
Kenya, Nairobi
Kenyatta University
Songok, Elijah Maritim
Kenya, Nairobi
Kenya Medical Research Institute
Kinyua, Joyceline Gaceri
Kenya, Nairobi
Kenya Medical Research Institute
Lagat, Nancy J.
Kenya, Nairobi
Kenya Medical Research Institute
Muriuki, Joseph K.
Kenya, Nairobi
Kenya Medical Research Institute
Lihana, Raphael Wekesa
Kenya, Nairobi
Kenya Medical Research Institute
Khamadi, Samoel Ashimosi
Kenya, Nairobi
Kenya Medical Research Institute
Osman, Saida
Kenya, Nairobi
Kenya Medical Research Institute
Lwembe, Raphael M.
Kenya, Nairobi
Kenya Medical Research Institute
Japan, Kanazawa
Kanazawa University
Kiptoo, Michael Kibet
Kenya, Nairobi
Kenya Medical Research Institute
Mwau, Matilu M.
Kenya, Nairobi
Kenya Medical Research Institute
Chirchir, Ruth
Kenya, Nairobi
Kenya Medical Research Institute
Mpoke, Solomon S.
Kenya, Nairobi
Kenya Medical Research Institute
Nyamongo, Jack A.
Unknown Affiliation
Okoth, Frederick A.
Kenya, Nairobi
Kenya Medical Research Institute
Yamada, Rika
Japan, Tokyo
Japan International Cooperation Agency
Kageyama, Seiji
Japan, Kanazawa
Kanazawa University
Ichimura, Hiroshi
Japan, Tokyo
Japan International Cooperation Agency
Japan, Kanazawa
Kanazawa University
Statistics
Citations: 31
Authors: 19
Affiliations: 5
Identifiers
Doi:
10.1159/000205526
ISSN:
03005526
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Kenya