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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Outcomes of controlled human malaria infection after BCG vaccination
Nature Communications, Volume 10, No. 1, Article 874, Year 2019
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Description
Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific memory characteristics, termed ‘trained immunity’. Here we present the results of a randomised, controlled phase 1 clinical trial in 20 healthy male and female volunteers to evaluate the induction of immunity and protective efficacy of the anti-tuberculosis BCG vaccine against a controlled human malaria infection. After malaria challenge infection, BCG vaccinated volunteers present with earlier and more severe clinical adverse events, and have significantly earlier expression of NK cell activation markers and a trend towards earlier phenotypic monocyte activation. Furthermore, parasitemia in BCG vaccinated volunteers is inversely correlated with increased phenotypic NK cell and monocyte activation. The combined data demonstrate that BCG vaccination alters the clinical and immunological response to malaria, and form an impetus to further explore its potential in strategies for clinical malaria vaccine development. © 2019, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6382772/bin/41467_2019_8659_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6382772/bin/41467_2019_8659_MOESM2_ESM.pdf
Authors & Co-Authors
Walk, Jona
Netherlands, Nijmegen
Radboud University Medical Center
de Bree, L. Charlotte J.
Netherlands, Nijmegen
Radboud University Medical Center
Denmark, Copenhagen
Statens Serum Institut
Denmark, Odense
Odense Universitetshospital
Graumans, Wouter
Netherlands, Nijmegen
Radboud University Medical Center
van Gemert, Geert Jan A.
Netherlands, Nijmegen
Radboud University Medical Center
van de Vegte-Bolmer, Marga G.
Netherlands, Nijmegen
Radboud University Medical Center
Teelen, Karina
Netherlands, Nijmegen
Radboud University Medical Center
Hermsen, Cornelus C.R.
Netherlands, Nijmegen
Radboud University Medical Center
Arts, Rob J.W.
Netherlands, Nijmegen
Radboud University Medical Center
Behet, Marije C.
Netherlands, Nijmegen
Radboud University Medical Center
Moorlag, Simone J.C.F.M.
Netherlands, Nijmegen
Radboud University Medical Center
van Crevel, Reinout
Netherlands, Nijmegen
Radboud University Medical Center
Aaby, Peter
Denmark, Copenhagen
Statens Serum Institut
de Mast, Quirijn
Netherlands, Nijmegen
Radboud University Medical Center
van der Ven, André J.A.M.
Netherlands, Nijmegen
Radboud University Medical Center
Benn, Christine Stabell
Denmark, Copenhagen
Statens Serum Institut
Denmark, Odense
Odense Universitetshospital
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Germany, Bonn
Universität Bonn
Sauerwein, Robert W.
Netherlands, Nijmegen
Radboud University Medical Center
Statistics
Citations: 142
Authors: 17
Affiliations: 5
Identifiers
Doi:
10.1038/s41467-019-08659-3
ISSN:
20411723
Research Areas
Infectious Diseases
Participants Gender
Male
Female