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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A study of the debrisoquine hydroxylation polymorphism in a nigerian population
Xenobiotica, Volume 10, No. 11, Year 1980
Notification
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Description
1. The metabolic oxidation of debrisoquine has been studied in a group of 123 Nigerian volunteers. 2. All subjects excreted unchanged drug together with five oxidation products, namely, 4-, 5-, 6-, 7- and 8-hydroxy-debrisoquine. 3. The 4-hydroxylation reaction exhibits polymorphism; ten subjects were defective in their ability to effect this reaction. 4. The incidence (q) of the allele governing impaired 4-hydroxylation (DL) among Nigerians was calculated as being 0.28 (95% confidence limit of 0.20-0.37). 5. An association was demonstrated between the ability to effect 4-hydroxylation and 6- and 7-hydroxylation of debrisoquine, suggesting that the alleles controlling alicyclic oxidation also influence aromatic hydroxylation. © 1980 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Authors & Co-Authors
Mbanefo, C. O.
Nigeria, Ibadan
University College Hospital, Ibadan
Bababunmi, Enitan A.
Nigeria, Ibadan
University of Ibadan
Mahgoub, A. A.
United Kingdom, London
Imperial College London
Sloan, T. P.
United Kingdom, London
Imperial College London
Idle, Jeffrey R.
United Kingdom, London
Imperial College London
Smith, Robert Løvsletten
United Kingdom, London
Imperial College London
Statistics
Citations: 71
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.3109/00498258009033811
ISSN:
00498254
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study